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Enhanced Dissolution of Ibuprofen Using Solid Dispersion with Poloxamer 407

Title
Enhanced Dissolution of Ibuprofen Using Solid Dispersion with Poloxamer 407
Author
최한곤
Keywords
Ibuprofen; Solid dispersions; Poloxamers; Solubility; Dissolution; Bioavailability
Issue Date
2008-11
Publisher
PHARMACEUTICAL SOCIETY KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v. 31, No. 11, Page. 1497-1507
Abstract
To improve its dissolution, ibuprofen solid dispersions (SDs) were prepared, characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR), and evaluated for solubility, and in-vitro ibuprofen release. Loss of individual surface properties during melting and re-solidification as revealed by SEM micrographs indicated the formation of effective SDs. Absence or shifting towards the lower melting temperature of the drug peak in SDs and physical mixtures in DSC study indicated the possibilities of drug-polymer interactions. FTIR spectra showed the presence of drug crystalline in SDs. The effect of improved dissolution on the oral absorption of ibuprofen in rats was also studied. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and C-max, and a significant decrease in T-max over pure ibuprofen. Comparison of the enhanced solubility, dissolution, AUC, and C-max of ibuprofen from different poloxamers suggested that the preparation of ibuprofen SDs using P 407 as a meltable hydrophilic polymer carrier could be a promising approach to improve its solubility, dissolution and absorption rate.
URI
https://link.springer.com/article/10.1007/s12272-001-2136-8http://repository.hanyang.ac.kr/handle/20.500.11754/80755
ISSN
0253-6269
DOI
10.1007/s12272-001-2136-8
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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