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Drug-induced hyperbilirubinemia and the clinical influencing factors

Title
Drug-induced hyperbilirubinemia and the clinical influencing factors
Author
김영미
Keywords
Hyperbilirubinemia; UGT1A1; OATP1B1; Multidrug resistance-associated protein 2 (MRA2); Genetic polymorphisms; Annual occurrence indices; Adverse drug reactions
Issue Date
2008-10
Publisher
TAYLOR & FRANCIS INC
Citation
DRUG METABOLISM REVIEWS, v. 40, No. 4, Page. 511-537
Abstract
Hyperbilirubinemia may accompany harmful effects such as jaundice, brain dysfunction, and pharmacokinetic alterations of drugs. Clinical drugs are the important causes of hyperbilirubinemia, especially for patients with certain pathologic conditions or with genetic variations. This article reviews hyperbilirubinemic pathophysiology with respect to the effects of clinical drugs. In addition, this review introduces a new formula that may be utilized to estimate the annual occurrences of drug-induced hyperbilirubinemia in a hospital. Variations in the genes of UDP-glucuronosyltransferases, organic anion-transporting polypeptides and multidrug resistance proteins are the predisposing factors for drug-induced hyperbilirubinemia; therefore, their genetic and ethnic polymorphisms are discussed.
URI
https://www.tandfonline.com/doi/abs/10.1080/03602530802341133http://repository.hanyang.ac.kr/handle/20.500.11754/80732
ISSN
0360-2532
DOI
10.1080/03602530802341133
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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