Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유혜현 | - |
dc.date.accessioned | 2018-12-03T05:24:41Z | - |
dc.date.available | 2018-12-03T05:24:41Z | - |
dc.date.issued | 2008-10 | - |
dc.identifier.citation | ARCHIVES OF PHARMACAL RESEARCH, v. 31, No. 10, Page. 1317-1323 | en_US |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007/s12272-001-2112-3 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/80709 | - |
dc.description.abstract | Halogenated organic compounds, such as 1-bromopentane (1-BPT), are used as cleaning agents, synthesis agents, or extraction solvents in the workplace. In the present study, glutathione (GSH) conjugation and hepatotoxicity induced by 1-BPT were investigated in female BALB/c mice. S-Bromopentyl GSH, S-bromopentyl cysteine, and mono-hydroxypentyl mercapturic acid were identified in liver by liquid chromatography-electrospray ionization tandem mass spectrometry. Oral treatment of mice with 1-BPT at 1500 mg/kg produced maximum GSH conjugates at 6 h after treatment. For hepatotoxicity tests, the animals were treated orally with 1-BPT at 375, 750, or 1500 mg/kg in corn oil once for a dose response study or at 1500 mg/kg for 6, 12, 24, or 48 h for a time course study. 1-BPT dose-dependently increased serum activity of ALT and AST and decreased hepatic GSH levels, peaking at 6 and 12 h after treatment. 1-BPT (750 and 1500 mg/kg) also significantly increased the hepatic content of malondialdehyde. Thus, 1-BPT could cause hepatotoxicity and depletion of GSH content by forming GSH conjugates, presenting a toxicity mechanism and potential biomarkers for low molecular weight haloalkanes. | en_US |
dc.description.sponsorship | This study was supported by a grant from the National Institute of Toxicological Research. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | PHARMACEUTICAL SOCIETY KOREA | en_US |
dc.subject | 1-Bromopentane | en_US |
dc.subject | Glutathione | en_US |
dc.subject | Conjugate structure | en_US |
dc.subject | Hepatotoxicity | en_US |
dc.subject | In vivo | en_US |
dc.subject | Mice | en_US |
dc.title | Identification of Glutathione Conjugates of 1-Bromopentane and its Hepatotoxicity in Female BALB/c Mice | en_US |
dc.type | Article | en_US |
dc.relation.volume | 31 | - |
dc.identifier.doi | 10.1007/s12272-001-2112-3 | - |
dc.relation.page | 1317-1323 | - |
dc.relation.journal | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.contributor.googleauthor | Lee, Sang Kyu | - |
dc.contributor.googleauthor | Lee, Dong Ju | - |
dc.contributor.googleauthor | Yoo, Hye Hyun | - |
dc.contributor.googleauthor | Kim, Ju Hyun | - |
dc.contributor.googleauthor | Seo, Young Nun | - |
dc.contributor.googleauthor | Shin, Sil | - |
dc.contributor.googleauthor | Choi, Jae Ho | - |
dc.contributor.googleauthor | Jeon, Tae Won | - |
dc.contributor.googleauthor | Kang, Mi Jeong | - |
dc.contributor.googleauthor | Jeong, Tae Cheon | - |
dc.relation.code | 2008200969 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | yoohh | - |
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