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Enhanced dissolution of ibuprofen using solid dispersion with polyethylene glycol 20000

Title
Enhanced dissolution of ibuprofen using solid dispersion with polyethylene glycol 20000
Author
최한곤
Keywords
ibuprofen; solid dispersions; polyethylene glycol 20000; solubility; dissolution; bioavailability
Issue Date
2008-10
Publisher
TAYLOR & FRANCIS INC
Citation
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, v. 34, No. 10, Page. 1013-1021
Abstract
To improve its dissolution, ibuprofen solid dispersions (SDs) were prepared in a relatively easy and simple manner, characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR), and evaluated for solubility and in vitro drug release. Loss of individual surface properties during melting and re-solidification as revealed by SEM micrographs indicated the formation of effective SDs. Absence or shifting toward the lower melting temperature of the drug peak in SDs in DSC study indicated the possibilities of drug-polymer interactions. FTIR spectra showed the presence of drug crystalline in SDs. The effect of improved dissolution on the oral absorption of ibuprofen in rats was also studied. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and C(max), and a significant decrease in T(max) over pure ibuprofen. Preliminary results from this study suggested that the preparation of fast dissolving ibuprofen SDs by low-temperature melting method using polyethylene glycol 20000 as a meltable hydrophilic polymer carrier could be a promising approach to improve solubility, dissolution, and absorption rate of ibuprofen.
URI
https://www.tandfonline.com/doi/abs/10.1080/03639040701744095http://repository.hanyang.ac.kr/handle/20.500.11754/80705
ISSN
0363-9045
DOI
10.1080/03639040701744095
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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