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Preparation and evaluation of fast dissolving ibuprofen-polyethylene glycol 6000 solid dispersions

Title
Preparation and evaluation of fast dissolving ibuprofen-polyethylene glycol 6000 solid dispersions
Author
최한곤
Keywords
ibuprofen; polyethylene glycol 6000; solid dispersion; dissolution; solubility; bioavailability
Issue Date
2008-08
Publisher
TAYLOR & FRANCIS INC
Citation
DRUG DELIVERY, v. 15, No. 6, Page. 355-364
Abstract
To improve its oral absorption, rapidly dissolving ibuprofen solid dispersions (SD) were prepared in a relatively easy, simple, quick, inexpensive, and reproducible manner, characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR). They were evaluated for solubility, in vitro release, and oral bioavailability of ibuprofen in rats. Loss of individual surface properties during melting and resolidification as revealed by SEM indicated the formation of effective SDs. Absence or shifting toward the lower melting temperature of the drug peak in SDs and physical mixtures in DSC study indicated the possibilities of drug-polymer interactions. However, no such interactions in the solid state were confirmed by FTIR spectra that showed the presence of drug crystalline in SDs. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and C(max), and a significant decrease in T(max) over pure ibuprofen. Preliminary results from this study suggested that the preparation of fast-dissolving ibuprofen SDs by low temperature melting method using PEG 6000 as a meltable hydrophilic polymer carrier could be a promising approach to improve solubility, dissolution, and absorption rate of ibuprofen.
URI
https://www.tandfonline.com/doi/abs/10.1080/10717540801952431http://repository.hanyang.ac.kr/handle/20.500.11754/80630
ISSN
1071-7544
DOI
10.1080/10717540801952431
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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