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dc.contributor.author최한곤-
dc.date.accessioned2018-11-22T01:22:00Z-
dc.date.available2018-11-22T01:22:00Z-
dc.date.issued2008-07-
dc.identifier.citationARCHIVES OF PHARMACAL RESEARCH, v. 31, No. 7, Page. 938-944en_US
dc.identifier.issn0253-6269-
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs12272-001-1250-1-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/80563-
dc.description.abstractInteraction of a drug with other drugs and dietary supplements is becoming an emerging issue for patients and health insurance authorities due to awareness of adverse drug event. In this study, we examined the effects of coenzyme Q10 (CoQ10), one of the most popular dietary supplements, on the pharmacokinetic parameters of theophylline in rats. The pharmacokinetic parameters of theophylline changed significantly when the drug was administered after five consecutive days of pretreatment with CoQ10. Time to reach maximum plasma concentration of theophylline delayed when the drug was administered after the pretreatment with CoQ10. Maximum plasma concentration and area under the curve of theophylline were about two-fold increased and other pharmacokinetic parameters such as half-life and volume of distribution were also changed significantly. Therefore, although CoQ10 is generally considered a safe dietary supplement, it appears that patients on theophylline therapy should use caution when they take CoQ10.en_US
dc.language.isoen_USen_US
dc.publisherPHARMACEUTICAL SOCIETY KOREAen_US
dc.subjecttheophyllineen_US
dc.subjectcoenzyme Q10en_US
dc.subjectpharmacokinetic parametersen_US
dc.subjectprotein bindingen_US
dc.subjectcytochrome P450en_US
dc.titleThe effect of coenzyme Q10 on the pharmacokinetic parameters of theophyllineen_US
dc.typeArticleen_US
dc.relation.volume31-
dc.identifier.doi10.1007/s12272-001-1250-1-
dc.relation.page938-944-
dc.relation.journalARCHIVES OF PHARMACAL RESEARCH-
dc.contributor.googleauthorBaskaran, Rengarajan-
dc.contributor.googleauthorShanmugam, Srinivasan-
dc.contributor.googleauthorNagayya-Sriraman, Santhoshkumar-
dc.contributor.googleauthorKim, Ju Hyun-
dc.contributor.googleauthorJeong, Tae Chun-
dc.contributor.googleauthorYong, Chul Soon-
dc.contributor.googleauthorChoi, Han-Gon-
dc.contributor.googleauthorYoo, Bong Kyu-
dc.relation.code2008200969-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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