Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신인철 | - |
dc.date.accessioned | 2018-11-19T02:43:51Z | - |
dc.date.available | 2018-11-19T02:43:51Z | - |
dc.date.issued | 2016-09 | - |
dc.identifier.citation | ONCOLOGY REPORTS, v. 36, NO. 3, Page. 1764-1771 | en_US |
dc.identifier.issn | 1021-335X | - |
dc.identifier.issn | 1791-2431 | - |
dc.identifier.uri | https://www.spandidos-publications.com/10.3892/or.2016.4977 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/80503 | - |
dc.description.abstract | Stanniocalcin-1 (STC-1), a secreted glycoprotein, is highly expressed in a variety of human malignancies. However, the role of STC-1 has not been fully elucidated in breast cancer cells. Here, we investigated whether STC-1 acts as a prognostic factor in triple-negative breast cancer (TNBC) patients, and we explored the cellular mechanism in breast cancer cells. The level of STC-1 expression was directly associated with the relapse-free and overall survival of basal-type breast cancer patients. Breast cancer patients with a high level of STC-1 had poor prognosis. In addition, our results showed that the level of STC-1 expression was markedly higher in TNBC than in non-TNBC cells. Invasiveness of the TNBC cells was also significantly increased in response to recombinant human STC-1 treatment. In contrast, the invaded cell numbers were completely decreased by STC-1 siRNA overexpression in the Hs578T and MDA-MB-231 TNBC cells. Our results showed that the phosphorylation of c-Jun N-terminal protein kinase (JNK) and c-Jun was increased after STC-1 treatment but not the phosphorylation of ERK and p38 MAPKs in the Hs578T and MDA-MB-231 TNBC cells. Furthermore, expression of one invasion-related gene MMP-9, was increased by STC-1 treatment. STC-1-induced MMP-9 expression was suppressed by SP600125 (a JNK inhibitor) in the Hs578T cells. STC-1-induced cell invasiveness was also inhibited by SP600125. Taken together, we demonstrated that aberrant STC-1 expression is associated with poor prognosis and stimulates the invasiveness of TNBC cells through the JNK/c-Jun-dependent signaling pathway. | en_US |
dc.description.sponsorship | This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2016R1D1A1B01010508). | en_US |
dc.language.iso | en | en_US |
dc.publisher | SPANDIDOS PUBL LTD | en_US |
dc.subject | stanniocalcin-1 | en_US |
dc.subject | prognosis | en_US |
dc.subject | triple-negative breast cancer | en_US |
dc.subject | cell invasion | en_US |
dc.subject | JNK | en_US |
dc.title | Elevated STC-1 augments the invasiveness of triple-negative breast cancer cells through activation of the JNK/c-Jun signaling pathway | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 36 | - |
dc.identifier.doi | 10.3892/or.2016.4977 | - |
dc.relation.page | 1764-1771 | - |
dc.relation.journal | ONCOLOGY REPORTS | - |
dc.contributor.googleauthor | Han, Jeonghun | - |
dc.contributor.googleauthor | Jeon, Myeongjin | - |
dc.contributor.googleauthor | Shin, Incheol | - |
dc.contributor.googleauthor | Kim, Sangmin | - |
dc.relation.code | 2016001362 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | incheol | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.