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ZIFIBI: Prediction of DNA binding sites for zinc finger proteins.

Title
ZIFIBI: Prediction of DNA binding sites for zinc finger proteins.
Author
이영식
Keywords
C2H2 zinc finger protein; cis-regulatory region; transcription factor; hidden markov model; transcription factor binding site
Issue Date
2008-04
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v. 369, No. 3, Page. 845-848
Abstract
The cis-regulatory region of target genes is key elements in the transcriptional regulation of gene expression. Many of these cis-regulatory regions have not been identified by either biological experiments or computational methods. Recently, a few additional C2H2 zinc finger transcription factor binding sites have been discovered. The majority of the zinc finger binding sites, however, are still unknown. In this study, we used publically available data to evaluate possible interaction patterns between nucleotides and the amino acids of zinc finger domains. We calculated the most probable state path of three nucleotides sequences using a Hidden Markov Model (HMM). We used these computations to predict C2H2 zinc finger transcription factor binding sites in cis-regulatory regions of their target genes (http://bioinfo.hanyang.ac.kr/ZIFIBI/frameset.php). (c) 2008 Elsevier Inc. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0006291X08003823http://repository.hanyang.ac.kr/handle/20.500.11754/80279
ISSN
0006-291X
DOI
10.1016/j.bbrc.2008.02.106
Appears in Collections:
COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > MOLECULAR AND LIFE SCIENCE(분자생명과학과) > Articles
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