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Evaluation of skin permeation and accumulation profiles of a highly lipophilic fatty ester

Title
Evaluation of skin permeation and accumulation profiles of a highly lipophilic fatty ester
Author
최한곤
Keywords
fatty esters; ketorolac stearate; skin permeation; skin accumulation; local topical agent
Issue Date
2008-02
Publisher
PHARMACEUTICAL SOCIETY KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v. 31, No. 2, Page. 242-249
Abstract
The aim was to evaluate the skin permeation and accumulation profiles of a highly lipophilic fatty ester using the combination of various permeation enhancing techniques to study the potential of highly lipophilic fatty esters as local topical agents. Permeation and accumulation profiles of ketorolac stearate (C18:0) were studied using solubility improved formulation, supersaturated solution of permeant in enhancer vehicle, lipophilic receptor solution, enhancer pretreatment, and the removal of stratum corneum and delipidization of skins. Impermeability and minimal skin accumulation of ketorolac stearate could delineate a preliminary possibility for designing safer topical agents without systemic absorption.
URI
https://link.springer.com/article/10.1007/s12272-001-1148-8http://repository.hanyang.ac.kr/handle/20.500.11754/76818
ISSN
0253-6269
DOI
10.1007/s12272-001-1148-8
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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