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Prevalence and possible causes of hypouricemia at a tertiary care hospital

Title
Prevalence and possible causes of hypouricemia at a tertiary care hospital
Author
김태환
Keywords
Hypouricemia; Uric acid
Issue Date
2016-09
Publisher
KOREAN ASSOC INTERNAL MEDICINE
Citation
KOREAN JOURNAL OF INTERNAL MEDICINE, v. 31, NO. 5, Page. 971-976
Abstract
Background/Aims: We aimed to investigate the prevalence and possible causes of hypouricemia in the Korean population and to compare our findings with published results of other populations. Methods: We examined the serum uric acid levels of 30,757 subjects who had their uric acid values measured at least once during a 1-year period. All individuals with hypouricemia (serum uric acid ˂ 2.0 mg/dL, n = 424) were reviewed with respect to medical drug history and concomitant diseases previously identified as being associated with hypouricemia. Results: The prevalence of hypouricemia was 4.14% (299/7,223) among inpatients and 0.53% (125/23,534) among outpatients, for an overall prevalence of 1.39% (424/30,757). Possible causes associated with hypouricemia were found to be solid or hematologic malignancies (n = 86), diabetes mellitus (n = 56), and therapeutic drugs (n = 29). The medications were allopurinol (n = 11), angiotensin II receptor blockers (n = 10), salicylates (n = 6), febuxostat (n = 1), and warfarin (n = 1). In the remaining 226 individuals, the cause of hypouricemia was not identified. Conclusions: Hypouricemia is relatively common in the Korean population compared to those of other countries. The possible causes associated with hypouricemia are related to underlying diseases and medications.
URI
http://kjim.org/journal/view.php?doi=10.3904/kjim.2015.125http://repository.hanyang.ac.kr/handle/20.500.11754/76617
ISSN
1226-3303; 2005-6648
DOI
10.3904/kjim.2015.125
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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