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Determination of acetaminophen using functional paper-based electrochemical devices

Title
Determination of acetaminophen using functional paper-based electrochemical devices
Author
성기훈
Keywords
Paper-based device; Acetaminophen; Electrochemical sensor; Carbon nanotube; Nanoparticle; Polyglutamic acid
Issue Date
2016-08
Publisher
ELSEVIER SCIENCE SA
Citation
SENSORS AND ACTUATORS B-CHEMICAL, v. 232, Page. 514-522
Abstract
In the present study, we constructed a functional paper fluidic device and evaluated its electrochemical performance by analyzing acetaminophen in the presence of ascorbic acid. The device was composed of a single-walled carbon nanotube (SWCNT) electrode and nafion-modified nitrocellulose membrane. Negatively-charged nafion was employed to build up a more negative charge on the nitrocellulose membrane, and gold nanoparticles and polyglutamic acid (AuNP-PGA) were deposited on the SWCNT electrode to enhance the electrochemical performance of the device. The device had a vertical flow format in which the sample solution flowed vertically through the paper. Using the nafion-modified nitrocellulose membrane and AuNP-PGAISWCNT film electrode as a component of the paper fluidic device, we obtained a distinguishable acetaminophen oxidation peak which was distinct from the ascorbic acid oxidation peak. The acetaminophen oxidation peak had a linear response with acetaminophen concentration, varying from 50 mu M to 300 mu M (r(2) = 0.992), which was broader than the standard drug dose range. The device exhibited a sensitivity of 13.3 mA/M and a detection limit of 15.0 mu M. The device was stable with a relative standard deviation of 3.3% (up to 2 weeks), and the reproducibility was 1.2-5.2%. Furthermore, the fabricated device accurately measured the amount of acetaminophen in pharmaceutical samples. (C) 2016 Elsevier B.V. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0925400516304634?via%3Dihubhttp://repository.hanyang.ac.kr/handle/20.500.11754/76450
ISSN
0925-4005
DOI
10.1016/j.snb.2016.03.169
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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