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Temperature-responsive Hydrogels Synthesized from Photo-Polymerizable Poloxamer Macromers for Topical Skin Moisturizing

Title
Temperature-responsive Hydrogels Synthesized from Photo-Polymerizable Poloxamer Macromers for Topical Skin Moisturizing
Author
김진웅
Keywords
Thermo-sensit ive hydrogels; Bis-acryloyl poloxamer; Reversible swelling behaviors; Skin moisturizing
Issue Date
2016-08
Publisher
WILEY-V C H VERLAG GMBH
Citation
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v. 37, NO. 8, Page. 1331-1336
Abstract
Temperature-responsive hydrogels were fabricated by the photo-polymerization of bis-acryloyl poloxamer tri-block copolymers, and their temperature-responsive behavior and physiological effect on skin were investigated. For this, poloxamer macromers were prepared by end-capping both terminal hydroxyl groups of poloxamer tri-block copolymers with acrylates. They were then photo-polymerized to generate polymeric hydrogels with structural integrity that allowed excellent stability against dilution in an aqueous environment. The resulting hydrogels exhibited dramatic reversible swelling behavior upon changes in temperature. A demonstration experiment, in which the hydrogels were applied topically to the skin, showed that they shrank rapidly as a result of the increase in temperature, owing to the contact with the skin surface, highlighting their effectiveness for instantaneously moisturizing the skin.
URI
https://onlinelibrary.wiley.com/doi/abs/10.1002/bkcs.10865http://repository.hanyang.ac.kr/handle/20.500.11754/76433
ISSN
0253-2964; 1229-5949
DOI
10.1002/bkcs.10865
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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