32 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author하정미-
dc.date.accessioned2018-10-11T00:57:23Z-
dc.date.available2018-10-11T00:57:23Z-
dc.date.issued2009-10-
dc.identifier.citationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v. 19, No. 23, Page. 6538-6543en_US
dc.identifier.issn0960-894X-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0960894X09014528-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/76430-
dc.description.abstractSynthesis of a new series of diarylureas and amides having pyrrolo[2,3-d]pyrimidine scaffold is described. Their in vitro antiproliferative activities against A375 human melanoma cell line and HS 27 fibroblast cell line were tested and the effect of substituents on pyrrolo[2,3-d]pyrimidine was investigated. The newly synthesized compounds, except N-acetyl derivatives (Id, Ie, and Im), generally showed superior or similar activity against A375 to Sorafenib. Among all of these derivatives, compounds Iq and Ir having imidazole and morpholine moieties, respectively, showed the most potent antiproliferative activity against A375. (C) 2009 Published by Elsevier Ltd.en_US
dc.description.sponsorshipWe are grateful to the Korea Institute of Science and Technology (KIST) for financial support.en_US
dc.language.isoen_USen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.subjectPyrrolo[2,3-d]pyrimidineen_US
dc.subjectA375en_US
dc.subjectHS 27Antiproliferative activityen_US
dc.subjectMelanomaen_US
dc.titleSynthesis of pyrrolo[2,3-d]pyrimidine derivatives and their antiproliferative activity against melanoma cell lineen_US
dc.typeArticleen_US
dc.relation.volume19-
dc.identifier.doi10.1016/j.bmcl.2009.10.051-
dc.relation.page6538-6543-
dc.relation.journalBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.contributor.googleauthorJung, Myung-Ho-
dc.contributor.googleauthorKim, Hwan-
dc.contributor.googleauthorChoi, Won-Kyoung-
dc.contributor.googleauthorEl-Gamal, Mohammed I.-
dc.contributor.googleauthorPark, Jin-Hun-
dc.contributor.googleauthorYoo, Kyung Ho-
dc.contributor.googleauthorSim, Tae Bo-
dc.contributor.googleauthorLee, So Ha-
dc.contributor.googleauthorBaek, Daejin-
dc.contributor.googleauthorHah, Jung-Mi-
dc.contributor.googleauthorCho, Jung-Hyuck-
dc.contributor.googleauthorOh, Chang-Hyun-
dc.relation.code2009201330-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidjhah-
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE