91 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author류종석-
dc.date.accessioned2018-09-28T08:15:57Z-
dc.date.available2018-09-28T08:15:57Z-
dc.date.issued2009-08-
dc.identifier.citationMOLECULAR AND CELLULAR BIOCHEMISTRY, v. 328, No. 1-2, Page. 177-182en_US
dc.identifier.issn0300-8177-
dc.identifier.urihttps://link.springer.com/article/10.1007/s11010-009-0087-4-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/76271-
dc.description.abstractPrion protein (PrP) interacts with some kringle domain-containing proteins. Kringle domains serve as binding domains in the interaction with PrP. The structural conservation among kringle domains leads to the hypothesis that any protein containing these domains can interact with PrP and be involved in prion pathogenesis. Because prion pathogenesis occurs in the brain, kringle domain-containing proteins should be available in the same tissue if they are relevant to prion pathogenesis. However, gene expression of these proteins in brains infected by prions has not been examined. Here, we showed that plasminogen (plg), urokinase type plasminogen activator (upa), tissue type plasminogen activator (tpa), prothrombin (prothr), and hepatocyte growth factor (hgf) genes were expressed in murine brains and neuroblastoma cells. The changes in upa, prothr, and hgf gene expression correlated with prion disease, but those in plg and tpa gene expression did not. Our data suggest association of gene expression of kringle domain-containing proteins in brains with prion disease.en_US
dc.description.sponsorshipThis study was supported by funds from the Sanders Brown Center on Aging, University of Kentucky.en_US
dc.language.isoen_USen_US
dc.publisherSPRINGERen_US
dc.subjectPrion diseaseen_US
dc.subjectGene expressionen_US
dc.subjectPlasminogenen_US
dc.subjectPlasminogen activatorsen_US
dc.subjectProthrombinen_US
dc.subjectHepatocyte growth factoren_US
dc.titleChanges in gene expression of kringle domain-containing proteins in murine brains and neuroblastoma cells infected by prionsen_US
dc.typeArticleen_US
dc.relation.no1-2-
dc.relation.volume328-
dc.identifier.doi10.1007/s11010-009-0087-4-
dc.relation.page177-182-
dc.relation.journalMOLECULAR AND CELLULAR BIOCHEMISTRY-
dc.contributor.googleauthorKim, Younghwan-
dc.contributor.googleauthorSong, Jihyun-
dc.contributor.googleauthorMays, Charles E.-
dc.contributor.googleauthorTitlow, William-
dc.contributor.googleauthorYoon, Donghoon-
dc.contributor.googleauthorRyou, Chongsuk-
dc.relation.code2009206797-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidcryou2-
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE