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dc.contributor.author최한곤-
dc.date.accessioned2018-09-21T02:03:30Z-
dc.date.available2018-09-21T02:03:30Z-
dc.date.issued2009-06-
dc.identifier.citationINTERNATIONAL JOURNAL OF PHARMACEUTICS, v. 377, No. 1-2, Page. 1-8en_US
dc.identifier.issn0378-5173-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0378517309002191-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/76150-
dc.description.abstractNiosomes have been reported as a possible approach to improve the low skin penetration and bioavailability characteristics shown by conventional topical vehicle for minoxidil. Niosomes formed from polyoxyethylene alkyl ethers (Brij™) or sorbitan monoesters (Span™) with cholesterol molar ratios of 0, 1 and 1.5 were prepared with varying drug amount 20–50mg using thin film-hydration method. The prepared systems were characterized for entrapment efficiency, particle size, zeta potential and stability. Skin permeation studies were performed using static vertical diffusion Franz cells and hairless mouse skin treated with either niosomes, control minoxidil solution (propylene glycol–water–ethanol at 20:30:50, v/v/v) or a leading topical minoxidil commercial formulation (Minoxyl). The results showed that the type of surfactant, cholesterol and incorporated amount of drug altered the entrapment efficiency of niosomes. Higher entrapment efficiency was obtained with the niosomes prepared from Span 60 and cholesterol at 1:1 molar ratio using 25mg drug. Niosomal formulations have shown a fairly high retention of minoxidil inside the vesicles (80%) at refrigerated temperature up to a period of 3 months. It was observed that both dialyzed and non-dialyzed niosomal formulations (1.03±0.18 to 19.41±4.04%) enhanced the percentage of dose accumulated in the skin compared to commercial and control formulations (0.11±0.03 to 0.48±0.17%) except dialyzed Span 60 niosomes. The greatest skin accumulation was always obtained with non-dialyzed vesicular formulations. Our results suggest that these niosomal formulations could constitute a promising approach for the topical delivery of minoxidil in hair loss treatment.en_US
dc.description.sponsorshipThis research was supported by the grant No. RTI04-01-04 from the Regional Technology Innovation Program of the Ministry of Knowledge Economy (MKE) and financially supported by a grant (R-01-2006-000-11230-0) from the Basic Research Program of the Korean Science and Engineering Foundation in South Korea.en_US
dc.language.isoen_USen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.subjectNiosomesen_US
dc.subjectMinoxidilen_US
dc.subjectStabilityen_US
dc.subjectPenetrationen_US
dc.subjectSkin accumulationen_US
dc.subjectDermal deliveryen_US
dc.subjectNONIONIC SURFACTANT VESICLESen_US
dc.subjectTRANSDERMAL DELIVERYen_US
dc.subjectDERMAL DELIVERYen_US
dc.subjectDRUG-DELIVERYen_US
dc.subjectLIPOSOMESen_US
dc.subjectCARRIERSen_US
dc.subjectPENETRATIONen_US
dc.subjectCHOLESTEROLen_US
dc.subjectRELEASEen_US
dc.subjectSYSTEMSen_US
dc.titleFormulation and in vitro assessment of minoxidil niosomes for enhanced skin deliveryen_US
dc.typeArticleen_US
dc.relation.volume377-
dc.identifier.doi10.1016/j.ijpharm.2009.04.020-
dc.relation.page1-8-
dc.relation.journalINTERNATIONAL JOURNAL OF PHARMACEUTICS-
dc.contributor.googleauthorBalakrishnan, Prabagar-
dc.contributor.googleauthorShanmugam, Srinivasan-
dc.contributor.googleauthorLee, Won Seok-
dc.contributor.googleauthorLee, Won Mo-
dc.contributor.googleauthorKim, Jong Oh-
dc.contributor.googleauthorOh, Dong Hoon-
dc.contributor.googleauthorKim, Dae-Duk-
dc.contributor.googleauthorKim, Jung Sun-
dc.contributor.googleauthorYoo, Bong Kyu-
dc.contributor.googleauthorChoi, Han-Gon-
dc.contributor.googleauthorWoo, Jong Soo-
dc.contributor.googleauthorYong, Chul Soon-
dc.relation.code2009204294-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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