Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2018-09-20T04:48:07Z | - |
dc.date.available | 2018-09-20T04:48:07Z | - |
dc.date.issued | 2009-06 | - |
dc.identifier.citation | ARCHIVES OF PHARMACAL RESEARCH, v. 32, No. 6, Page. 893-898 | en_US |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007/s12272-009-1611-5 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/76129 | - |
dc.description.abstract | To develop a novel tacrolimus-loaded solid dispersion with improved solubility, various solid dispersions were prepared with various ratios of water, sodium lauryl sulfate, citric acid and carboxylmethylcellulose-Na using spray drying technique. The physicochemical properties of solid dispersions were investigated using scanning electron microscopy, differential scanning calorimetery and powder X-ray diffraction. Furthermore, their solubility and dissolution were evaluated compared to drug powder. The solid dispersion at the tacrolimus/CMC-Na/sodium lauryl sulfate/citric acid ratio of 3/24/3/0.2 significantly improved the drug solubility and dissolution compared to powder. The scanning electron microscopy result suggested that carriers might be attached to the surface of drug in this solid dispersion. Unlike traditional solid dispersion systems, the crystal form of drug in this solid dispersion could not be converted to amorphous form, which was confirmed by the analysis of DSC and powder X-ray diffraction. Thus, the solid dispersion system with water, sodium lauryl sulfate, citric acid and CMC-Na should be a potential candidate for delivering a poorly water-soluble tacrolimus with enhanced solubility and no convertible crystalline. | en_US |
dc.description.sponsorship | This research was supported by the Yeungnam University research grants in 2008. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | PHARMACEUTICAL SOCIETY KOREA | en_US |
dc.subject | Solid dispersion | en_US |
dc.subject | Tacrolimus | en_US |
dc.subject | Sodium carboxylmethyl cellulose | en_US |
dc.subject | Sodium lauryl sulfate | en_US |
dc.subject | Solubility | en_US |
dc.title | Physicochemical characterization of tacrolimus-loaded solid dispersion with sodium carboxylmethyl cellulose and sodium lauryl sulfate | en_US |
dc.type | Article | en_US |
dc.relation.volume | 32 | - |
dc.identifier.doi | 10.1007/s12272-009-1611-5 | - |
dc.relation.page | 893-898 | - |
dc.relation.journal | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.contributor.googleauthor | Park, Young-Joon | - |
dc.contributor.googleauthor | Ryu, Dong-Sung | - |
dc.contributor.googleauthor | Li, Dong Xun | - |
dc.contributor.googleauthor | Quan, Qi Zhe | - |
dc.contributor.googleauthor | Oh, Dong Hoon | - |
dc.contributor.googleauthor | Kim, Jong Oh | - |
dc.contributor.googleauthor | Seo, Youn Gee | - |
dc.contributor.googleauthor | Lee, Young-Im | - |
dc.contributor.googleauthor | Yong, Chul Soon | - |
dc.contributor.googleauthor | Woo, Jong Soo | - |
dc.contributor.googleauthor | Choi, Han-Gon | - |
dc.relation.code | 2009200969 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hangon | - |
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