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dc.contributor.author배옥남-
dc.date.accessioned2018-09-19T00:15:20Z-
dc.date.available2018-09-19T00:15:21Z-
dc.date.issued2009-05-
dc.identifier.citationPLATELETS, v. 20, No. 3, Page. 163-170en_US
dc.identifier.issn0953-7104-
dc.identifier.urihttps://www.tandfonline.com/doi/abs/10.1080/09537100902721746-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/76090-
dc.description.abstractNeuronal accumulation of 1-methyl-4-phenylpyridinium ion (MPP+), the metabolite of neural toxin, 1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine (MPTP), induces a rapid depletion of cellular ATP level and loss of neuronal cell viability which simulates human Parkinson's disease (PD). Since ATP plays an important role in the physiology and function of platelets, which share many biochemical and physiological features with neuronal cells, we examined the effect of MPP+ on platelet aggregation and viability using freshly isolated rat platelets. While the treatment of MPP+ to platelets did not induce cytotoxicity, it significantly attenuated agonist-induced platelet aggregation in a concentration dependent manner. The inhibition of aggregation by MPP+ was mediated by the depletion of the cytoplasmic ATP pool and resultant decreased ATP secretion. Different from the previous reports in neuronal cells, MPP+ did not affect intracellular levels of glutathione and cytoplasmic Ca2+ in platelets. The combined treatment with MPP+ and 2-deoxyglucose, a glycolysis inhibitor, showed the additive effect in the decrease of ATP secretion and intracellular content. Consistent with these findings, inhibitory effects of MPP+ on platelet aggregation was significantly enhanced by the treatment with 2-deoxyglucose. In conclusion, these results suggested that MPP+ can induce ATP depletion in platelets and attenuate platelet aggregation providing a new theory on the reduced platelet activities in PD patients.en_US
dc.description.sponsorshipThis work was supported by the Grants from Chemical Safety and Health Agency, and KOSEF grant funded by the MOST (R01-2007-000-11252-0).en_US
dc.language.isoen_USen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.subjectMPTPen_US
dc.subjectMPP+en_US
dc.subjectATPen_US
dc.subjectplatelet aggregationen_US
dc.subjectParkinson's diseaseen_US
dc.subjectCOMPLEX-Ien_US
dc.subjectDOPAMINERGIC NEURONen_US
dc.subjectP2X(1) RECEPTORSen_US
dc.subjectBINDING-SITESen_US
dc.subjectMPTPen_US
dc.subjectGLUTATHIONEen_US
dc.subjectNEUROTOXINen_US
dc.subjectPATHWAYen_US
dc.subjectMODELen_US
dc.subjectMELATONINen_US
dc.titleInhibition of platelet aggregation by 1-methyl-4-phenyl pyridinium ion (MPP plus ) through ATP depletion: Evidence for the reduced platelet activities in Parkinson's diseaseen_US
dc.typeArticleen_US
dc.relation.no3-
dc.relation.volume20-
dc.identifier.doi10.1080/09537100902721746-
dc.relation.page163-170-
dc.relation.journalPLATELETS-
dc.contributor.googleauthorLim, SueKyung-Min-
dc.contributor.googleauthorKim, Hyun-Hee-
dc.contributor.googleauthorBae, Ok-Nam-
dc.contributor.googleauthorNoh, Ji-Yoon-
dc.contributor.googleauthorKim, Keun-Young-
dc.contributor.googleauthorKim, Sae-Hwan-
dc.contributor.googleauthorChung, Seung-Min-
dc.contributor.googleauthorShin, Sue-
dc.contributor.googleauthorKim, Hyeon-Yeong-
dc.contributor.googleauthorChung, Jin-Ho-
dc.relation.code2009207695-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidonbae-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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