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dc.contributor.author최한곤-
dc.date.accessioned2018-09-17T01:59:28Z-
dc.date.available2018-09-17T01:59:28Z-
dc.date.issued2009-05-
dc.identifier.citationINTERNATIONAL JOURNAL OF PHARMACEUTICS, v. 374, No. 1-2, Page. 66-72en_US
dc.identifier.issn0378-5173-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0378517309001367-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/75169-
dc.description.abstractTo enhance the solubility and bioavailability of poorly water-soluble Coenzyme Q(10) (CoQ(10)), self-emulsifying drug delivery system (SEDDS) composed of oil, surfactant and cosurfactant for oral administration of CoQ(10) was formulated. The solubility of CoQ(10) was determined in various oils and surfactants. The formulations were prepared using two oils (Labrafil M 1944 and Labrafil M 2125), surfactant (Labrasol) and cosurfactant (Lauroglycol FCC and Capryol 90). In all the formulations, the level of CoQ(10) was fixed at 6% (w/v) of the vehicle. These formulations were characterized by solubility of the drug in the vehicle, particle size of the dispersed emulsion, zeta potential and drug release profile. Ternary phase diagrams were used to evaluate the emulsification domain. The self-emulsification time following introduction into an aqueous medium under gentle agitation was evaluated. The optimized SEDDS formulation consist of 65% (v/v) Labrasol, 25% (v/v) Labrafil M 1944 CS and 10% (v/v) Capryol 90 of each excipient showed minimum mean droplet size (about 240 nm) and optimal drug release profile in water. The pharmacokinetic study in rats for the optimized formulation was performed and compared to powder formulation. SEDDS have significantly increased the C-max and area under the curve (AUC) of CoQ(10) compared to powder (P ˂ 0.05). Thus, this self-micro emulsifying drug delivery system should be an effective oral dosage form for improving oral bioavailability of lipophilic drug, CoQ(10). (C) 2009 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipThis research was supported by the grant no. RT104-01-04 from the Regional Technology Innovation Program of the Ministry of Knowledge Economy (MKE) and financially supported by the Ministry of Science and Technology (M10414030001-05N1403-00140) in South Korea.en_US
dc.language.isoen_USen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.subjectCoenzyme Q(10)en_US
dc.subjectSelf-emulsifying drug delivery systemen_US
dc.subjectSolubilityen_US
dc.subjectBioavailabilityen_US
dc.subjectINTESTINAL-ABSORPTIONen_US
dc.subjectFORMULATIONen_US
dc.subjectRATSen_US
dc.subjectMECHANISMSen_US
dc.subjectEMULSIONen_US
dc.subjectLABRASOLen_US
dc.subjectPERMEABILITYen_US
dc.subjectDISSOLUTIONen_US
dc.subjectGLYCERIDESen_US
dc.subjectSMEDDSen_US
dc.titleEnhanced oral bioavailability of Coenzyme Q(10) by self-emulsifying drug delivery systemsen_US
dc.typeArticleen_US
dc.relation.no1-2-
dc.relation.volume374-
dc.identifier.doi10.1016/j.ijpharm.2009.03.008-
dc.relation.page66-72-
dc.relation.journalINTERNATIONAL JOURNAL OF PHARMACEUTICS-
dc.contributor.googleauthorBalakrishnan, Prabagar-
dc.contributor.googleauthorLee, Beom-Jin-
dc.contributor.googleauthorOh, Dong Hoon-
dc.contributor.googleauthorKim, Jong Oh-
dc.contributor.googleauthorLee, Young-Im-
dc.contributor.googleauthorKim, Dae-Duk-
dc.contributor.googleauthorJee, Jun-Pil-
dc.contributor.googleauthorLee, Yong-Bok-
dc.contributor.googleauthorWoo, Jong Soo-
dc.contributor.googleauthorYong, Chul Soon-
dc.contributor.googleauthorChoi, Han-Gon-
dc.relation.code2009204294-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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