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Development of novel ibuprofen-loaded solid dispersion with improved bioavailability using aqueous solution

Title
Development of novel ibuprofen-loaded solid dispersion with improved bioavailability using aqueous solution
Author
최한곤
Keywords
Solid dispersion; Ibuprofen; Solubility; Pharmacokinetics
Issue Date
2009-05
Publisher
PHARMACEUTICAL SOCIETY KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v. 32, No. 5, Page. 767-772
Abstract
To develop a novel ibuprofen-loaded solid dispersion with enhanced bioavailability, various ibuprofen-loaded solid dispersions were prepared with water, HPMC and poloxamer. The effect of HPMC and poloxamer on aqueous solubility of ibuprofen was investigated. The dissolution and bioavailability of solid dispersion in rats were then evaluated compared to ibuprofen powder. When the amount of carrier increased with a decreased in HPMC/poloxamer ratio, the aqueous solubility of ibuprofen was elevated. The solid dispersion composed of ibuprofen/HPMC/poloxamer at the weight ratio of 10:3:2 improved the drug solubility approximately 4 fold. It gave significantly higher initial plasma concentration, AUC and Cmax of drug than did ibuprofen powder in rats. The solid dispersion improved the bioavailability of drug about 4-fold compared to ibuprofen powder. Thus, this ibuprofen-loaded solid dispersion with water, HPMC and poloxamer was a more effective oral dosage form for improving the bioavailability of poor water-soluble ibuprofen.
URI
https://link.springer.com/article/10.1007/s12272-009-1516-3http://repository.hanyang.ac.kr/handle/20.500.11754/75079
ISSN
0253-6269
DOI
10.1007/s12272-009-1516-3
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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