Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김동욱 | - |
dc.date.accessioned | 2018-09-10T00:58:14Z | - |
dc.date.available | 2018-09-10T00:58:15Z | - |
dc.date.issued | 2009-01 | - |
dc.identifier.citation | INTERNATIONAL IMMUNOPHARMACOLOGY, v. 9, No. 1, Page. 127-133 | en_US |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1567576908003299?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/75035 | - |
dc.description.abstract | Lipoteichoic acid (LTA) is a major immunostimulating component in the cell wail of Gram-positive bacteria as lipopolysaccharide of Gram-negative bacteria. However, LTA is expressed on not only pathogenic but also nonpathogenic Gram-positive bacteria. In order to examine whether the immunostimulating potentials of Gram-positive bacteria are correlated with their LTAs, we prepared highly pure LTAs from Staphylococcus aureus (pathogenic), Bacillus subtilis (non-pathogenic), or Lactobacillus plantarum (beneficial). When a murine macrophage cell-line, RAW 264.7, was stimulated with heat-killed bacteria, both S. aureus and B.subtilis induced nitric oxide (NO) production in a close-dependent manner while L plantarum showed a minimal induction. Interestingly, purified LTAs from S. aureus and B. subtilis, but not from L. plantarum, were able to induce the production of NO. The differential inflammatory potentials of LTAs coincided with their abilities to activate Toll-like receptor 2 (TLR2), which is known to recognize Gram-positive bacteria and LTA, and transcription factors NF-kappa B and AP-1. Similar results were obtained with the expression of cytokines related to inflammation by RAW 264.7 and human peripheral blood mononuclear cells as well. The ability of LTA to induce TNF-alpha and NO production was abolished when the LTAs were treated with 0.2 N NaOH. Collectively, we suggest that the immunostimulating potentials of Gram-positive bacteria differ due to their LTAs with differential potencies in the stimulation of TLR2. (C) 2008 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by the 21 C Frontier Microbial Genomics and Applications Center Program (MGAC) and the Korea Science and Engineering Foundation (KOSEF) Science Research Center grant through Bone Metabolism Research Center, Ministry of Education, Science & Technology, Republic of Korea, and by the Seoul National University's financial support program for the new faculty. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | Gram-positive bacteria | en_US |
dc.subject | Lipoteichoic acid | en_US |
dc.subject | Innate immunity | en_US |
dc.subject | Toll-like receptor | en_US |
dc.subject | MULTIPLE ORGAN FAILURE | en_US |
dc.subject | NITRIC-OXIDE SYNTHASE | en_US |
dc.subject | NECROSIS-FACTOR-ALPHA | en_US |
dc.subject | TOLL-LIKE RECEPTOR-2 | en_US |
dc.subject | STAPHYLOCOCCUS-AUREUS | en_US |
dc.subject | CYTOKINE INDUCTION | en_US |
dc.subject | TEICHOIC-ACIDS | en_US |
dc.subject | LIPOPOLYSACCHARIDE | en_US |
dc.subject | PEPTIDOGLYCAN | en_US |
dc.subject | COMPONENTS | en_US |
dc.title | Differential immunostimulatory effects of Gram-positive bacteria due to their lipoteichoic acids | en_US |
dc.type | Article | en_US |
dc.relation.volume | 9 | - |
dc.identifier.doi | 10.1016/j.intimp.2008.10.014 | - |
dc.relation.page | 127-133 | - |
dc.relation.journal | INTERNATIONAL IMMUNOPHARMACOLOGY | - |
dc.contributor.googleauthor | Ryu, Young Hee | - |
dc.contributor.googleauthor | Baik, Jung Eun | - |
dc.contributor.googleauthor | Yang, Jae Seung | - |
dc.contributor.googleauthor | Kang, Seok-Seong | - |
dc.contributor.googleauthor | Im, Jintaek | - |
dc.contributor.googleauthor | Yun, Cheol-Heui | - |
dc.contributor.googleauthor | Kim, Dong Wook | - |
dc.contributor.googleauthor | Lee, Kangseok | - |
dc.contributor.googleauthor | Chung, Dae Kyun | - |
dc.contributor.googleauthor | Ju, Hyang Ran | - |
dc.contributor.googleauthor | Han, Seung Hyun | - |
dc.relation.code | 2009204108 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | dongwook | - |
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