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Maternal exercise reduces hyperthermia-induced apoptosis in developing mouse brain

Title
Maternal exercise reduces hyperthermia-induced apoptosis in developing mouse brain
Author
김성민
Keywords
maternal hyperthermia; maternal exercise; apoptosis; heat shock proteins; Hsp70 knockout (KO) mouse embryos
Issue Date
2011-09
Publisher
TAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
Citation
INTERNATIONAL JOURNAL OF HYPERTHERMIA, Vol.27, No.5 [2011], p445-452
Abstract
Purpose: Hyperthermia-induced apoptosis is mediated by mitochondrial pathway, and is temporally correlated with alterations in mitochondrial morphology in neuroepithelial cells. In addition, regular exercise up-regulates heat shock proteins (HSPs) that inhibit apoptosis. However, embryo-protective effects of maternal exercise against heat exposure during pregnancy have not been fully understood yet.Materials and methods: To investigate the role of maternal exercise in protecting embryos from hyperthermia, we measured apoptosis-related factors and HSPs in Hsp70 knockout mouse embryos. Pregnant mice were divided into control, exercise, hyperthermia-after-exercise, and hyperthermia groups. Where appropriate the swimming exercise was performed for 5-10 min/day from embryonic day (ED) 1 to ED 8, and hyperthermia (43 degrees C, 5 min) was induced on ED 8. To characterise the effects of maternal exercise on apoptosis-related factors and HSPs, we performed western blotting and transmission electron microscopy.Results: Caspase-9, -7, -3 and Bax were down-regulated in the hyperthermia-after-exercise group and Bcl-2, Hsp27 and Hsp110 were up-regulated. The number of apoptotic cells was markedly reduced in the hyperthermia-after-exercise group.Conclusions: Maternal exercise plays an important role in inhibiting apoptotic cell death in embryos against hyperthermic exposure during pregnancy.
URI
https://www.tandfonline.com/doi/abs/10.3109/02656736.2011.569967?journalCode=ihyt20http://repository.hanyang.ac.kr/handle/20.500.11754/74912
ISSN
0265-6736
DOI
10.3109/02656736.2011.569967
Appears in Collections:
COLLEGE OF ART AND PHYSICAL EDUCATION[S](예술·체육대학) > PHYSICAL EDUCATION(체육학과) > Articles
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