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A small molecule inhibitor of alpha 4 integrin-dependent cell migration

Title
A small molecule inhibitor of alpha 4 integrin-dependent cell migration
Author
남태규
Keywords
COTTON-TOP TAMARIN; GAMMA-PARVIN; ANTAGONISTS; ANTIBODY; KINASE; LIBRARIES; COLITIS; BINDING
Issue Date
2009-02
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY, v. 17, No. 3, Page. 977-980
Abstract
A small molecule inhibitor of alpha 4 integrin-dependent cell migration was identified through a cell-based screen of small molecule libraries. Biochemical and cellular experiments suggest that this molecule functions by interacting with gamma-parvin. This molecule should serve as a useful tool to study alpha 4 integrin signaling and may lead to new therapeutics for the treatment of autoimmune diseases. (C) 2008 Elsevier Ltd. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0968089608001879http://repository.hanyang.ac.kr/handle/20.500.11754/74649
ISSN
0968-0896
DOI
10.1016/j.bmc.2008.02.067
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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