36 0

Determination of mirodenafil and sildenafil in the plasma and corpus cavernous of SD male rats

Title
Determination of mirodenafil and sildenafil in the plasma and corpus cavernous of SD male rats
Author
유혜현
Keywords
Mirodenafil; Sildenafil; Tissue distribution; LC-MS/MS; PHARMACOKINETICS; IDENTIFICATION; METABOLISM
Issue Date
2009-02
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, v. 49, No. 2, Page. 513-518
Abstract
The purpose of the present study was to determine sildenafil and a novel PDE-5 inhibitor, mirodenafil in the plasma and corpus cavernosum tissue of rats to compare their pharmacokinetic Properties. The concentrations of mirodenafil and sildenafil in the rat plasma and corpus cavernosum tissue samples were analyzed using LC-MS/MS after a single oral administration at a dose of 40 mg/kg to rats. Although the T(max), D lambda(1/2) and MRT were not different between mirodenafil and sildenafil, the C(max) and AUC of mirodenafil were significantly higher than those of sildenafil in the plasma and corpus cavernosum tissue. Consequently mirodenafil remained longer than sildenafil in the plasma and tissue. This may provide pharmacokinetic evidence for assessment of the in vivo efficacy of mirodenafil and sildenafil. (C) 2008 Elsevier B.V. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0731708508006055http://repository.hanyang.ac.kr/handle/20.500.11754/74617
ISSN
0731-7085
DOI
10.1016/j.jpba.2008.11.004
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE