Anti-hypertensive effect of Korean red ginseng by enrichment of ginsenoside Rg3 and arginine-fructose
- Title
- Anti-hypertensive effect of Korean red ginseng by enrichment of ginsenoside Rg3 and arginine-fructose
- Author
- 이현규
- Keywords
- arginine-fructose; blood pressure; ginsenoside Rg3; hypotensive components-enriched; Korean Red Ginseng
- Issue Date
- 2016-07
- Publisher
- KOREAN SOC GINSENG
- Citation
- JOURNAL OF GINSENG RESEARCH, Page. 237-244
- Abstract
- Background
Ginsenoside Rg3 and arginine–fructose (Arg-Fru) are known as the hypotensive compounds of Panax ginseng; however, their efficacy on antihypertension has not been reported yet to our best knowledge. Thus, hypotensive components-enriched fraction of red ginseng (HCEF-RG) was prepared from fine root concentrate (FR) and their antihypertensive effects were investigated in spontaneously hypertensive rats (SHR).
Methods
Male SHRs were divided into six groups: control (Wistar Kyoto, SHR); FR 500; FR 1,000; HCEF-RG 500; and HCEF-RG 1,000; samples (mg/kg body weight) were orally administered every day for 8 wk. Blood pressure was monitored at 1 wk, 2 wk, 3 wk, 4 wk, 6 wk, and 8 wk by tail cuff method. At 8 wk after samples administration, mice were killed for the measurement of renin activity (RA), angiotensin-I converting enzyme inhibition, angiotensin II, and nitric oxide (NO) levels in plasma.
Results
HCEF-RG with four-fold more Rg3 and 24-fold more Arg-Fru contents was successfully prepared from reacted mixtures of FR and persimmon vinegar (12 times against FR, v/v) at 80°C for 18 h. Both FR 1,000 and HCEF-RG 1,000 showed lowered systolic blood pressure than SHR control group and HCEF-RG 1,000 group exhibited a significant decrease in diastolic blood pressure. RA was significantly lowered in all treated groups, while angiotensin II did not affect by FR and HCEF-RG treatment. However, angiotensin-I converting enzyme inhibition and NO in FR 1,000 and HCEF-RG 1,000 were significantly increased compared with SHR control group.
Conclusion
HCEF-RG is more effective and useful for alleviating hypertension than FR, implying the health benefit of Rg3 and Arg-Fru.
- URI
- https://www.sciencedirect.com/science/article/pii/S1226845315000779?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/74472
- ISSN
- 1226-8453; 2093-4947
- DOI
- 10.1016/j.jgr.2015.08.002
- Appears in Collections:
- COLLEGE OF HUMAN ECOLOGY[S](생활과학대학) > FOOD & NUTRITION(식품영양학과) > Articles
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