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Positive immunostaining of Sal-like protein 4 is associated with poor patient survival outcome in the large and undifferentiated Korean hepatocellular carcinoma

Title
Positive immunostaining of Sal-like protein 4 is associated with poor patient survival outcome in the large and undifferentiated Korean hepatocellular carcinoma
Author
백승삼
Keywords
SALL4 protein; Hepatocellular carcinoma; Prognosis; Immunohistochemistry; Microarray analysis
Issue Date
2016-07
Publisher
KOREAN SURGICAL SOCIETY
Citation
ANNALS OF SURGICAL TREATMENT AND RESEARCH, v. 91, NO 1, Page. 23-28
Abstract
Purpose: Previous studies have shown the role of Sal-like protein 4 (SALL4) as a biomarker in hepatocellular carcinoma (HOC), and some studies have shown the relationship between SALL4 and prognosis. Given the debates in study groups differences in terms of etiologic causes between Western and Asian HCC and detection methods, we attempted to verify the features of SALL4 immunoreactivity and its clinical correlation in Korean HCC patients. Methods: Immunohistochemical staining of SALL4 of tissue microarrays (TMAs) consisting of 213 surgically resected HCC patients' tissue were scored in a semiquantitative scoring system with immunoreactive score and the results analyzed with clinical outcome, in addition to general demographics and clinical characteristics. Results: SALL4 immunoreactivity was expressed in 50 cases. Relevance between SALL4 and alpha-FP correlated significantly (P = 0.002). Also, the SALL4-positive patients had considerably higher tumor grade (P ˂ 0.001). The survival analysis showed negative correlation with SALL4 immunoreactivity in all HCC patient groups, but SALL4 immunoreactivity in T3 and T4 HCC correlated with poor prognosis. Conclusion: Here, we found that positive immunostaining of SALL4 is correlated with poor patient survival outcome in large and undifferentiated Korean HCC. SALL4 expression showed close relationship with clinical outcomes of HCCs in Korean patients.
URI
https://synapse.koreamed.org/DOIx.php?id=10.4174/astr.2016.91.1.23http://repository.hanyang.ac.kr/handle/20.500.11754/74378
ISSN
2288-6575; 2288-6796
DOI
10.4174/astr.2016.91.1.23
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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