Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer

Title
Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer
Authors
KAUSHIKNEHA
Keywords
radiation; EMT; Notch signaling; interleukin-6; breast cancer
Issue Date
2016-07
Publisher
IMPACT JOURNALS LLC
Citation
ONCOTARGET, v. 7, NO 33, Page. 53430-53442
Abstract
Epithelial to mesenchymal transition (EMT) is developmental process associated with cancer metastasis. Here, we found that breast carcinoma cells adopt epithelial-to-mesenchymal transition (EMT) in response to fractionated-radiation. Importantly, we show that Notch signaling is highly activated in fractionally-irradiated tumors as compared to non-irradiated tumors that are accompanied by an EMT. Moreover, we uncovered the mechanism of Notch-driven EMT, in which Notch enhanced EMT through IL-6/JAK/STAT3 signaling axis in mammary tumor cells. Collectively, we present converging evidence from our studies that Notch2 is a critical mediator of radiation-induced EMT and responsible for induced malignant tumor growth.
URI
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=10802&path[]=34200http://repository.hanyang.ac.kr/handle/20.500.11754/74331
ISSN
1949-2553
DOI
http://dx.doi.org/10.18632/oncotarget.10802
Appears in Collections:
RESEARCH INSTITUTE[S](부설연구소) > THE RESEARCH INSTITUTE FOR NATURAL SCIENCES(자연과학연구소) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE