Factors influencing clinicians' choice of adjuvant S-1 versus capecitabine plus oxaliplatin after curative gastrectomy in patients with gastric cancer
- Title
- Factors influencing clinicians' choice of adjuvant S-1 versus capecitabine plus oxaliplatin after curative gastrectomy in patients with gastric cancer
- Author
- 원영웅
- Keywords
- stomach neoplasms; chemotherapy; adjuvant; gastrectomy
- Issue Date
- 2016-07
- Publisher
- Ivyspring International Publisher
- Citation
- Journal of Cancer, v. 7, NO 12, Page. 1711-1715
- Abstract
- Purpose: Two recent randomized, phase III trials in Asia (ACTS-GC and CLASSIC) documented the survival benefit of postoperative chemotherapy after D2 lymph node dissection in patients with gastric cancer. We sought to determine what factors influenced clinicians' choices of either S-1 or capecitabine plus oxaliplatin (CAPOX) as adjuvant therapy after curative D2 gastrectomy.
Materials and Methods: We retrospectively reviewed the clinicopathologic factors and adjuvant treatments for 435 patients from nine centers in Korea who were treated with either S-1 or CAPOX adjuvant chemotherapy after undergoing curative D2 gastrectomy between January 2013 and July 2014.
Results: Of the 435 patients, 204 (46.9%) were treated with S-1 and 231 (53.1%) were treated with CAPOX. The median age at diagnosis was 61 years (range, 30-88). CAPOX was prescribed more often for patients who were 65 years of age or younger than for patients who were age 65 or older (77.1% vs. 22.9%, P<0.0001). Of the patients in stage II, 121 (60.8%) were treated with S-1 and 78 (39.2%) were given CAPOX; however, of those in stage III, 83 (35.2%) received S-1 and 153 (64.8%) were treated with CAPOX (P<0.0001).
Conclusions: Clinicians only preferred CAPOX for younger patients with stage III gastric cancer after curative D2 gastrectomy. However, for elderly patients, clinicians more chose S-1 regardless of the stage.
- URI
- http://www.jcancer.org/v07p1711.htmhttps://repository.hanyang.ac.kr/handle/20.500.11754/74305
- ISSN
- 1837-9664
- DOI
- 10.7150/jca.15598
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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