Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이수재 | - |
dc.date.accessioned | 2018-07-27T05:50:18Z | - |
dc.date.available | 2018-07-27T05:50:18Z | - |
dc.date.issued | 2011-06 | - |
dc.identifier.citation | Toxicology and Applied Pharmacology, VOL,254, NO.1, JUL 1 2011 , pp.32-40 | en_US |
dc.identifier.issn | 0041-008X | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0041008X11001359?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/73571 | - |
dc.description.abstract | A subpopulation of cancer cells with stem cell properties is responsible for tumor maintenance and progression, and may contribute to resistance to anticancer treatments. Thus, compounds that target cancer stem-like cells could be usefully applied to destroy cancer. In this study, we investigated the effect of Eckol, a phlorotannin compound, on sternness and malignancies in glioma stem-like cells. To determine whether Eckol targets glioma stem-like cells, we examined whether Eckol treatment could change the expression levels of glioma stem-like cell markers and self-renewal-related proteins as well as the sphere forming ability, and the sensitivity to anticancer treatments. Alterations in the malignant properties of sphere-derived cells by Eckol were also investigated by soft-agar colony forming assay, by xenograft assay in nude mice, and by cell invasion assay.Treatment of sphere-forming glioma cells with Eckol effectively decreased the sphere formation as well as the CD133(+) cell population. Eckol treatment suppressed expression of the glioma stem-like cell markers and the self-renewal-related proteins without cell death. Moreover, treatment of glioma stem-like cells with Eckol significantly attenuated anchorage-independent growth on soft agar and tumor formation in xenograft mice. Importantly, Eckol treatment effectively reduced the resistance of glioma stem-like cells to ionizing radiation and temozolomide. Treatment of glioma stem-like cells with Eckol markedly blocked both phosphoinositide 3-kinase-Akt and Ras-Raf-1-Erk signaling pathways.These results indicate that the natural phlorotannin Eckol suppresses sternness and malignancies in glioma stem-like cells, and thereby makes glioma stem-like cells more sensitive to anticancer treatments, providing novel therapeutic strategies targeting specifically cancer stem-like cells. | en_US |
dc.description.sponsorship | This work was supported by the Korea Research Foundation (KRF) and Ministry of Education, Science and Technology (MEST), Korean government, through its National Nuclear Technology Program (2008-2003935). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA | en_US |
dc.subject | Eckol | en_US |
dc.subject | Glioma stem-like cells | en_US |
dc.subject | Self-renewal | en_US |
dc.subject | Malignant phenotype | en_US |
dc.subject | Resistance to anticancer treatments | en_US |
dc.title | Eckol suppresses maintenance of sternness and malignancies in glioma stem-like cells | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 254 | - |
dc.identifier.doi | 10.1016/j.taap.2011.04.006 | - |
dc.relation.page | 32-40 | - |
dc.relation.journal | TOXICOLOGY AND APPLIED PHARMACOLOGY | - |
dc.contributor.googleauthor | Hyun, Kyung-Hwan | - |
dc.contributor.googleauthor | Yoon, Chang-Hwan | - |
dc.contributor.googleauthor | Kim, Rae-Kwon | - |
dc.contributor.googleauthor | Lim, Eun-Jung | - |
dc.contributor.googleauthor | An, Sungkwan | - |
dc.contributor.googleauthor | Park, Myung-Jin | - |
dc.contributor.googleauthor | Hyun, Jin-Won | - |
dc.contributor.googleauthor | Suh, Yongjoon | - |
dc.contributor.googleauthor | Kim, Min-Jung | - |
dc.contributor.googleauthor | Lee, Su-Jae | - |
dc.relation.code | 2011209519 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | sj0420 | - |
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