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Mortality factors in idiopathic inflammatory myopathy: focusing on malignancy and interstitial lung disease

Title
Mortality factors in idiopathic inflammatory myopathy: focusing on malignancy and interstitial lung disease
Author
김태환
Keywords
Death; Dermatomyositis; Malignancy; Polymyositis; Prognosis
Issue Date
2013-05
Publisher
Springer
Citation
Modern Rheumatology May 2013, Volume 23, Issue 3, pp 503?508
Abstract
ObjectivesThe objective of this study was to assess the incidence and common types of concomitant malignancies and to define predictive factors of death in Korean patients with idiopathic inflammatory myopathy (IIM).MethodsFrom January 1989 to May 2011, 162 patients were diagnosed with IIM at a university hospital in Korea. The medical records were retrospectively reviewed. The clinical findings of the patients were compared for malignancy, and the prognostic factors predicting death were analyzed.ResultsMalignancies were found in 17 patients (10.5 %), all of whom had a significantly lower frequency of interstitial lung disease (ILD) and an older age at onset. The main causes of death were ILD and malignancy. Older age at diagnosis, presence of malignancy, rapidly progressive ILD and minimal creatinine phosphokinase (CPK) elevation were independent risk factors for death.ConclusionsMalignancy was one of the most serious risk factor for death in our patients with IIM. Early discovery of malignancy is important, and an extensive investigation for common malignancies in each region should be done at diagnosis and for a minimum of 2 years thereafter. As minimally elevated CPK levels in ILD patients may be associated with fatal ILD, an early evaluation and a more aggressive treatment of ILD should be considered in these patients.
URI
http://link.springer.com/article/10.1007%2Fs10165-012-0673-2https://www.tandfonline.com/doi/abs/10.3109/s10165-012-0673-2http://repository.hanyang.ac.kr/handle/20.500.11754/73113
ISSN
1439-7595
DOI
10.1007/s10165-012-0673-2
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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