Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신흥수 | - |
dc.date.accessioned | 2018-07-26T02:24:31Z | - |
dc.date.available | 2018-07-26T02:24:31Z | - |
dc.date.issued | 2012-07 | - |
dc.identifier.citation | Microvascular Research, 2012, 84(1), p.1-8 | en_US |
dc.identifier.issn | 0026-2862 | - |
dc.identifier.issn | 1095-9319 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0026286212000891 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/73053 | - |
dc.description.abstract | Stem cell transplantation can induce neovascularization. Regenerated blood vessels should remain stable for a long-term period in order to function as new blood vessels in ischemic tissues. Here we show that local delivery of FGF2 enhances the long-term (12 weeks) angiogenic efficacy of human adipose-derived stem cells (hADSCs) implanted into mouse ischemic hindlimbs. Following transplantation of hADSCs into ischemic hindlimbs of mice, hADSC viability was significantly higher in the hADSC + FGF2 group at 4 and 12 weeks post-transplantation than in the hADSC only group. Furthermore, hADSCs produced higher levels of angiogenic growth factors (i.e., fibroblast growth factor 2, vascular endothelial growth factor, hepatocyte growth factor, and platelet-derived growth factor) at both time points. As a result, the density of arterioles in the ischemic hindlimb muscle was significantly higher in the hADSC + FGF2 group than in either hADSC or FGF2 only group at both time points. The number of arterioles with larger diameters was significantly greater in the hADSC + FGF2 group than in the other groups at 12 weeks, and increased in the hADSC + FGF2 group as the time period increased from 4 weeks to 12 weeks post-transplantation. This suggests that FGF2 delivery to hADSC transplantation sites enhances long-term angiogenic efficacy of hADSCs transplanted into ischemic tissues. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science B.V., Amsterdam | en_US |
dc.title | Enhancement of long-term angiogenic efficacy of adipose stem cells by delivery of FGF2 | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 84 | - |
dc.identifier.doi | 10.1016/j.mvr.2012.04.004 | - |
dc.relation.page | 1-8 | - |
dc.relation.journal | MICROVASCULAR RESEARCH | - |
dc.contributor.googleauthor | Lee, T. J. | - |
dc.contributor.googleauthor | Bhang, S. H. | - |
dc.contributor.googleauthor | Yang, H. S. | - |
dc.contributor.googleauthor | La, W. G. | - |
dc.contributor.googleauthor | Yoon, H. H. | - |
dc.contributor.googleauthor | Shin, J. Y. | - |
dc.contributor.googleauthor | Seong, J. Y. | - |
dc.contributor.googleauthor | Shin, H. | - |
dc.contributor.googleauthor | Kim, B. S. | - |
dc.relation.code | 2012206708 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | hshin | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.