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Enhancement of long-term angiogenic efficacy of adipose stem cells by delivery of FGF2

Title
Enhancement of long-term angiogenic efficacy of adipose stem cells by delivery of FGF2
Author
신흥수
Issue Date
2012-07
Publisher
Elsevier Science B.V., Amsterdam
Citation
Microvascular Research, 2012, 84(1), p.1-8
Abstract
Stem cell transplantation can induce neovascularization. Regenerated blood vessels should remain stable for a long-term period in order to function as new blood vessels in ischemic tissues. Here we show that local delivery of FGF2 enhances the long-term (12 weeks) angiogenic efficacy of human adipose-derived stem cells (hADSCs) implanted into mouse ischemic hindlimbs. Following transplantation of hADSCs into ischemic hindlimbs of mice, hADSC viability was significantly higher in the hADSC + FGF2 group at 4 and 12 weeks post-transplantation than in the hADSC only group. Furthermore, hADSCs produced higher levels of angiogenic growth factors (i.e., fibroblast growth factor 2, vascular endothelial growth factor, hepatocyte growth factor, and platelet-derived growth factor) at both time points. As a result, the density of arterioles in the ischemic hindlimb muscle was significantly higher in the hADSC + FGF2 group than in either hADSC or FGF2 only group at both time points. The number of arterioles with larger diameters was significantly greater in the hADSC + FGF2 group than in the other groups at 12 weeks, and increased in the hADSC + FGF2 group as the time period increased from 4 weeks to 12 weeks post-transplantation. This suggests that FGF2 delivery to hADSC transplantation sites enhances long-term angiogenic efficacy of hADSCs transplanted into ischemic tissues.
URI
https://www.sciencedirect.com/science/article/abs/pii/S0026286212000891https://repository.hanyang.ac.kr/handle/20.500.11754/73053
ISSN
0026-2862; 1095-9319
DOI
10.1016/j.mvr.2012.04.004
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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