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beta-PIX Is Critical for Transplanted Mesenchymal Stromal Cell Migration

Title
beta-PIX Is Critical for Transplanted Mesenchymal Stromal Cell Migration
Author
고성호
Issue Date
2012-07
Publisher
Mary Ann Liebert, Inc. publishers
Citation
Stem Cells and Development,2012, 21(11), p.1989~ 2088
Abstract
Bone marrow-derived mesenchymal stromal cells (MSCs) have been used successfully as a source of stem cells for treating neurodegenerative diseases. However, for reasons that are not clear, autologous MSC transplants have not yielded successful results in human trials. To test one possible reason, we compared the migratory ability of MSCs from amyotrophic lateral sclerosis (ALS) patients with those of healthy controls. We found that MSCs derived from ALS patients (ALS-MSCs) had a reduced ability to migrate, which may explain why autologous transplantation is not successful. We also found that expression of one of the intracellular factors implicated in migration, beta-PIX, was significantly reduced in ALS-MSCs compared with healthy stem cells. Restoration of beta-PIX expression by genetic manipulation restored the migratory ability of ALS-MSCs, and inhibition of beta-PIX expression with shRNA reduced the migration of healthy MSCs. We suggest that transplantation of allogeneic or genetically modified autologous stem cells might be a more promising strategy for ALS patients than transplantation of autologous stem cells.
URI
https://www.liebertpub.com/doi/abs/10.1089/scd.2011.0430?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmedhttp://repository.hanyang.ac.kr/handle/20.500.11754/73049
ISSN
1525-8165; 1557-8534
DOI
10.1089/scd.2011.0430
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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