42 0

Histopathological spectrum of cutaneous tuberculosis and nontuberculous mycobacterial infections

Title
Histopathological spectrum of cutaneous tuberculosis and nontuberculous mycobacterial infections
Author
민경환
Keywords
Mycobacterium tuberculosis; non-tuberculousmycobacterium; infection
Issue Date
2012-06
Publisher
American Society of Dermatopathology
Citation
Journal of Cutaneous Pathology, 2012, 39(6), p.582-595
Abstract
The non-specific clinical findings and variable histopathologicalfeatures of cutaneous tuberculosis and non-tuberculous mycobacterialinfections often make it difficult to establish a diagnosis and initiateappropriate therapy. We investigated 25 patients diagnosed withmycobacterial infections of the skin in Hanyang University Hospitalbetween 2001 and 2011. Skin biopsy specimens were re-evaluated byvarious histopathological criteria and molecular studies. To identify themycobacteria, we performed staining for acid-fast bacilli and alsocompleted polymerase chain reaction analysis. The non-tuberculousmycobacterium species were identified by genetic sequencing offormalin-fixed, paraffin-embedded tissues. Immunocompromised statuswas more frequent in non-tuberculous mycobacterial infections than intuberculosis (p = 0.017) while disease duration was longer intuberculosis (p = 0.026). Microscopically, neutrophil infiltration,interstitial granuloma, small vessel proliferation and increased numbersof bacilli were found to be associated with non-tuberculousmycobacterial infections (all p < 0.05). In contrast, giant cells, plasmacells, tuberculoid granulomas and necrosis were associated withtuberculosis (all p < 0.05). There were no species-specifichistopathological findings in non-tuberculous mycobacterial infections.The significant histopathological differences between cutaneoustuberculous and non-tuberculous mycobacterial infections are helpfulin considering differential diagnoses. In addition, molecular techniquestogether with clinico-pathological findings may assist in makingaccurate diagnoses of cutaneous non-tuberculous mycobacterialinfections.
URI
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0560.2012.01903.xhttp://repository.hanyang.ac.kr/handle/20.500.11754/73022
ISSN
0303-6987; 1600-0560
DOI
10.1111/j.1600-0560.2012.01903.x
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE