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Association between Serum Stromal Cell-Derived Factor-1 alpha and Long-Term Outcome of Acute Ischemic Stroke

Title
Association between Serum Stromal Cell-Derived Factor-1 alpha and Long-Term Outcome of Acute Ischemic Stroke
Author
이규용
Keywords
Stromal cell-derived factor-1 alpha; Ischemic stroke; Stroke outcome; Neurotrophic effect
Issue Date
2012-05
Publisher
KARGER
Citation
European Neurology, 2012, 67(6), P.363-369
Abstract
Background: Stromal cell-derived factor-1 alpha (SDF-1 alpha) provides neurotrophic support to neurons. In this prospective study, we investigated the association between SDF-1 alpha and long-term outcome in patients with acute ischemic stroke. Methods: This study included 104 patients with first-ever ischemic stroke, identified within 24 h of symptom onset. Serum samples were collected immediately after admission and 3 months thereafter, as well as from age- and sex-matched normal controls. The correlation between acute-stage serum SDF-1 alpha and stroke severity were analyzed. Finally, the relationship between serum SDF-1 alpha and long-term outcome was evaluated by multivariate analysis. Results: Serum SDF-1 alpha levels were only higher in acute-stage stroke patients compared with the normal control group (p = 0.011). The serum SDF-1 alpha level was increased in proportion to infarct volume (r = 0.220, p = 0.025) and initial National Institutes of Health Stroke Scale score (r = 0.275, p = 0.005). After adjustment for covariates, a high initial serum SDF-1 alpha level (OR 1.167, p = 0.023) or second and third tertiles of SDF-1 alpha level compared to first tertile (OR 4.644, p = 0.044 and OR 9.396, p = 0.025, respectively) were significantly associated with a favorable long-term outcome. Conclusions: This prospective study demonstrated a correlation between serum SDF-1 alpha and favorable long-term outcome in patients with acute ischemic stroke.
URI
https://www.karger.com/Article/Abstract/335351http://repository.hanyang.ac.kr/handle/20.500.11754/73000
ISSN
0014-3022
DOI
10.1159/000335351
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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