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Hydrophobic binding peptide-conjugated hybrid lipid-mesoporous silica nanoparticles for effective chemo-photothermal therapy of pancreatic cancer

Title
Hydrophobic binding peptide-conjugated hybrid lipid-mesoporous silica nanoparticles for effective chemo-photothermal therapy of pancreatic cancer
Author
최한곤
Keywords
Bortezomib; hydrophobic-binding peptide; IR-820; pancreatic cancer; chemo-phototherapy; CELL-PENETRATING PEPTIDES; LIQUID-CRYSTALLINE NANOPARTICLES; NEAR-INFRARED DYE; DRUG-DELIVERY; LIPOSOMES; EFFICACY
Issue Date
2017-12
Publisher
TAYLOR & FRANCIS LTD
Citation
DRUG DELIVERY, v. 24, No. 1, Page. 1690-1702
Abstract
Nanoparticle-based drug delivery systems are designed to reach tumor sites based on their enhanced permeation and retention effects. However, a lack of interaction of these nanoparticles with cancer cells might lead to reduced uptake in the tumors, which might compromise the therapeutic efficacy of the system. Therefore, we developed bortezomib and IR-820-loaded hybrid-lipid mesoporous silica nanoparticles conjugated with the hydrophobic-binding peptide, cyclosporine A (CsA), and referred to them as CLMSN/BIR. Upon reaching the tumor site, CsA interacts hydrophobically with the cancer cell membranes to allow effective uptake of the nanoparticles. Nanoparticles similar to 160nm in size were prepared and the stability of IR-820 significantly improved. High cellular uptake of the nanoparticles was evident with pronounced apoptotic effects in PANC-1 and MIA PaCa-2 cells that were mediated by the chemotherapeutic effect of bortezomib and the photothermal and reactive oxygen species generation effects of IR-820. An in vivo biodistribution study indicated there was high accumulation in the tumor with an enhanced photothermal effect in PANC-1 xenograft mouse tumors. Furthermore, enhanced antitumor effects in PANC-1 xenograft tumors were observed with minimal toxicity induction in the organs of mice. Cumulatively, these results indicated the promising effects of CLMSN/BIR for effective chemo-phototherapy of pancreatic cancers.
URI
https://www.tandfonline.com/doi/abs/10.1080/10717544.2017.1396382http://repository.hanyang.ac.kr/handle/20.500.11754/72683
ISSN
1071-7544; 1521-0464
DOI
10.1080/10717544.2017.1396382
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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