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Light-switchable systems for remotely controlled drug delivery

Title
Light-switchable systems for remotely controlled drug delivery
Author
최한곤
Keywords
Light-switchable system; Remotely controlled delivery; Photothermal activation; Photochemical activation; Photoisomerization; NEAR-INFRARED LIGHT; PHOTODYNAMIC THERAPY; CANCER-CHEMOTHERAPY; CONTAINING POLYMERS; MESOPOROUS SILICA; ENDOSOMAL ESCAPE; NIR LIGHT; NANOPARTICLES; RELEASE; CELLS
Issue Date
2017-12
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF CONTROLLED RELEASE, v. 267, No. Special SI, Page. 67-79
Abstract
Light-switchable systems have recently received attention as a new mode of remotely controlled drug delivery. In the past, a multitude of nanomedicine studies have sought to enhance the specificity of drug delivery to target sites by focusing on receptors overexpressed on malignant cells or environmental features of diseases sites. Despite these immense efforts, however, there are few clinically available nanomedicines. We need a paradigm shift in drug delivery. One strategy that may overcome the limitations of pathophysiology-based drug delivery is the use of remotely controlled delivery technology. Unlike pathophysiology-based active drug targeting strategies, light-switchable systems are not affected by the heterogeneity of cells, tissue types, and/or microenvironments. Instead, they are triggered by remote light (i.e., near-infrared) stimuli, which are absorbed by photoresponsive molecules or three-dimensional nanostructures. The sequential conversion of light to heat or reactive oxygen species can activate drug release and allow it to be spatio-temporally controlled. Light-switchable systems have been used to activate endosomal drug escape, modulate the release of chemical and biological drugs, and alter nanoparticle structures to control the release rates of drugs. This review will address the limitations of pathophysiology-based drug delivery systems, the current status of light-based remote-switch systems, and future directions in the application of light-switchable systems for remotely controlled drug delivery.
URI
https://www.sciencedirect.com/science/article/pii/S0168365917308416http://repository.hanyang.ac.kr/handle/20.500.11754/72680
ISSN
0168-3659; 1873-4995
DOI
10.1016/j.jconrel.2017.09.009
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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