Local injection of Granulocyte-colony stimulating factor accelerates wound healing in a rat excisional wound model

Title
Local injection of Granulocyte-colony stimulating factor accelerates wound healing in a rat excisional wound model
Authors
송이선
Keywords
Granulocyte-colony stimulating factor; Wound healing; Local injection
Issue Date
2016-06
Publisher
KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC
Citation
TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v. 13, NO 3, Page. 297-303
Abstract
A systemic treatment of granulocyte-colony stimulating factor (G-CSF) is known to improve healings of damaged tissues. However, recent studies suggested local actions of G-CSF on the healing processes of damaged tissues. We investigated the treatment effect of locally injected G-CSF and compared to that of systemically injected G-CSF in a rat model. A wound was created on the rat dorsum and treated either by local injection or by systemic injection of G-CSF. Wound healing rate, deposition of collagen, and gene expression were evaluated. G-CSF receptor (G-CSFR) protein was detected by Western blotting. The wound healing rate in the local injection group was significantly higher than that in the systemic injection group at days 9 and 15; it was also significantly higher than that in the control group at days 3, 9, and 15. The expression of G-CSFR protein in wound tissues was higher than in normal skin tissues. The local injection of G-CSF is more effective than systemic injection of G-CSF in promoting wound healing, which may implicate the local action of G-CSF treatment in wound healing processes.
URI
https://link.springer.com/article/10.1007%2Fs13770-016-9054-9http://repository.hanyang.ac.kr/handle/20.500.11754/72445
ISSN
1738-2696
DOI
http://dx.doi.org/10.1007/s13770-016-9054-9
Appears in Collections:
RESEARCH INSTITUTE[S](부설연구소) > ETC
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