Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유혜현 | - |
dc.date.accessioned | 2018-06-28T02:17:08Z | - |
dc.date.available | 2018-06-28T02:17:09Z | - |
dc.date.issued | 2017-05 | - |
dc.identifier.citation | JOURNAL OF ANALYTICAL TOXICOLOGY, v. 41, No. 4, Page. 334-339 | en_US |
dc.identifier.issn | 0146-4760 | - |
dc.identifier.issn | 1945-2403 | - |
dc.identifier.uri | https://academic.oup.com/jat/article/41/4/334/2871216 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/72255 | - |
dc.description.abstract | Alcohol ethoxylates (AEs) are a major class of non-ionic surfactants, which are widely used in household, institutional and industrial cleaners, and they are considered as an alternative of nonylphenol. In this study, a rapid, sensitive and reliable bioanalytical method was developed for the determination of octaethylene glycol monodecyl ether (C10E8, an AE) in rat plasma using liquid chromatography-tandem mass spectrometry (LC-MS-MS). Chromatographic separation was performed on a reversed-phase C18 column (2.1 mm x 50 mm, 2.1 mu m). The mobile phase consisted of 0.1% formic acid in distilled water and 0.1% formic acid in acetonitrile (40:60% v/v). The flow rate was 0.3 mL/min. For mass spectrometric detection, the multiple reaction monitoring (MRM) mode was used; the MRM transitions were m/z 511.5 -> m/z 133.1 for C10E8 and m/z 423.3 -> m/z 133.1 for hexaethylene glycol monodecyl ether (internal standard) in the positive ion mode. A calibration curve was constructed within the range of 2-2,000 ng/mL; the intra- (n = 5) and inter-day (n = 3) precision and accuracy were within 10%. The LC-MS-MS method was specific, accurate and reproducible, and this method was successfully applied in a pharmacokinetic study of C10E8 in rats. C10E8 was intravenously (1 mg/kg, n = 6) and orally (10 mg/kg, n = 7) administered to rats. The kinetic parameters were analyzed based on a noncompartmental statistical model using the pharmacokinetic modeling software (WinNonlin). The oral bioavailability of C10E8 was 34.4%. | en_US |
dc.description.sponsorship | This research was supported by the Civil research projects for solving social problems through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2015M3C8A6A06012996). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | OXFORD UNIV PRESS INC | en_US |
dc.subject | FATTY ALCOHOL ETHOXYLATES | en_US |
dc.subject | NONIONIC SURFACTANTS | en_US |
dc.subject | BIODEGRADATION | en_US |
dc.subject | NONYLPHENOL | en_US |
dc.subject | TOXICITY | en_US |
dc.subject | PATHWAYS | en_US |
dc.subject | HUMANS | en_US |
dc.title | Liquid Chromatography-Tandem Mass Spectrometric Analysis of Octaethylene Glycol Monodecyl Ether in Rat Plasma and its Application to Pharmacokinetic Studies | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1093/jat/bkw134 | - |
dc.relation.page | 334-339 | - |
dc.relation.journal | JOURNAL OF ANALYTICAL TOXICOLOGY | - |
dc.contributor.googleauthor | Kim, Hyeon | - |
dc.contributor.googleauthor | Kim, Hyeong Jun | - |
dc.contributor.googleauthor | Choi, Min Sun | - |
dc.contributor.googleauthor | Kim, In Sook | - |
dc.contributor.googleauthor | Gye, Myung Chan | - |
dc.contributor.googleauthor | Yoo, Hye Hyun | - |
dc.relation.code | 2017003443 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | yoohh | - |
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