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dc.contributor.author유혜현-
dc.date.accessioned2018-06-28T02:17:08Z-
dc.date.available2018-06-28T02:17:09Z-
dc.date.issued2017-05-
dc.identifier.citationJOURNAL OF ANALYTICAL TOXICOLOGY, v. 41, No. 4, Page. 334-339en_US
dc.identifier.issn0146-4760-
dc.identifier.issn1945-2403-
dc.identifier.urihttps://academic.oup.com/jat/article/41/4/334/2871216-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/72255-
dc.description.abstractAlcohol ethoxylates (AEs) are a major class of non-ionic surfactants, which are widely used in household, institutional and industrial cleaners, and they are considered as an alternative of nonylphenol. In this study, a rapid, sensitive and reliable bioanalytical method was developed for the determination of octaethylene glycol monodecyl ether (C10E8, an AE) in rat plasma using liquid chromatography-tandem mass spectrometry (LC-MS-MS). Chromatographic separation was performed on a reversed-phase C18 column (2.1 mm x 50 mm, 2.1 mu m). The mobile phase consisted of 0.1% formic acid in distilled water and 0.1% formic acid in acetonitrile (40:60% v/v). The flow rate was 0.3 mL/min. For mass spectrometric detection, the multiple reaction monitoring (MRM) mode was used; the MRM transitions were m/z 511.5 -> m/z 133.1 for C10E8 and m/z 423.3 -> m/z 133.1 for hexaethylene glycol monodecyl ether (internal standard) in the positive ion mode. A calibration curve was constructed within the range of 2-2,000 ng/mL; the intra- (n = 5) and inter-day (n = 3) precision and accuracy were within 10%. The LC-MS-MS method was specific, accurate and reproducible, and this method was successfully applied in a pharmacokinetic study of C10E8 in rats. C10E8 was intravenously (1 mg/kg, n = 6) and orally (10 mg/kg, n = 7) administered to rats. The kinetic parameters were analyzed based on a noncompartmental statistical model using the pharmacokinetic modeling software (WinNonlin). The oral bioavailability of C10E8 was 34.4%.en_US
dc.description.sponsorshipThis research was supported by the Civil research projects for solving social problems through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2015M3C8A6A06012996).en_US
dc.language.isoen_USen_US
dc.publisherOXFORD UNIV PRESS INCen_US
dc.subjectFATTY ALCOHOL ETHOXYLATESen_US
dc.subjectNONIONIC SURFACTANTSen_US
dc.subjectBIODEGRADATIONen_US
dc.subjectNONYLPHENOLen_US
dc.subjectTOXICITYen_US
dc.subjectPATHWAYSen_US
dc.subjectHUMANSen_US
dc.titleLiquid Chromatography-Tandem Mass Spectrometric Analysis of Octaethylene Glycol Monodecyl Ether in Rat Plasma and its Application to Pharmacokinetic Studiesen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/jat/bkw134-
dc.relation.page334-339-
dc.relation.journalJOURNAL OF ANALYTICAL TOXICOLOGY-
dc.contributor.googleauthorKim, Hyeon-
dc.contributor.googleauthorKim, Hyeong Jun-
dc.contributor.googleauthorChoi, Min Sun-
dc.contributor.googleauthorKim, In Sook-
dc.contributor.googleauthorGye, Myung Chan-
dc.contributor.googleauthorYoo, Hye Hyun-
dc.relation.code2017003443-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidyoohh-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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