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Irinotecan-encapsulated double-reverse thermosensitive nanocarrier system for rectal administration

Title
Irinotecan-encapsulated double-reverse thermosensitive nanocarrier system for rectal administration
Author
최한곤
Keywords
Irinotecan; double reverse thermosensitive nanocarrier; rectal administration; burst effect; toxicity; anti-tumor efficacy
Issue Date
2017-07
Publisher
TAYLOR & FRANCIS LTD
Citation
DRUG DELIVERY, v. 24, No. 1, Page. 502-510
Abstract
Intravenously administered for the treatment of rectum cancer, irinotecan produces severe side effects due to very high plasma concentrations. A novel irinotecan-encapsulated double reverse thermosensitive nanocarrier system (DRTN) for rectal administration was developed as an alternative. The DRTN was fabricated by dispersing the thermosensitive irinotecan-encapsulated solid lipid nanoparticles (SLN) in the thermosensitive poloxamer solution. Its gel properties, pharmacokinetics, morphology, anticancer activity and immunohistopathology were assessed after its rectal administration to rats and tumor-bearing mice. In the DRTN, the solid form of the SLN and the liquid form of the poloxamer solution persisted at 25 degrees C; the former melted to liquid, and the latter altered to gel at 36.5 degrees C. The DRTN was easily administered to the anus, gelling rapidly and strongly after rectal administration. Compared to the conventional hydrogel and intravenously administered solution, it retarded dissolution and initial plasma concentration. The DRTN gave sustained release and nearly constant plasma concentrations of irinotecan at 1-3 h in rats, resulting in improved anticancer activity. It induced no damage to the rat rectum and no body weight loss in tumor-bearing mice. Thus, this irinotecan-encapsulated DRTN associated with a reduced burst effect, lack of toxicity and excellent antitumor efficacy would be strongly recommended as a rectal pharmaceutical product alternative to commercial intravenous injection in the treatment of rectum and colon cancer.
URI
https://www.tandfonline.com/doi/abs/10.1080/10717544.2016.1272651https://repository.hanyang.ac.kr/handle/20.500.11754/72229
ISSN
1071-7544; 1521-0464
DOI
10.1080/10717544.2016.1272651
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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