48 0

Sustained release docetaxel-incorporated lipid nanoparticles with improved pharmacokinetics for oral and parenteral administration

Title
Sustained release docetaxel-incorporated lipid nanoparticles with improved pharmacokinetics for oral and parenteral administration
Author
김진기
Keywords
Lipid nanoparticles; docetaxel; sustained release; pharmacokinetics; bioavailability; CONTROLLED DRUG-DELIVERY; IN-VIVO EVALUATION; ANTICANCER DRUGS; TUMOR MICROENVIRONMENT; VITRO; CYTOTOXICITY; NANOCARRIERS; CARRIERS; SYSTEMS; SLN
Issue Date
2017-06
Publisher
TAYLOR & FRANCIS LTD
Citation
JOURNAL OF MICROENCAPSULATION, v. 34, No. 3, Page. 250-261
Abstract
The aim of this study was to develop docetaxel-incorporated lipid nanoparticles (DTX-NPs) to improve the pharmacokinetic behaviour of docetaxel (DTX) after oral and parenteral administration via sustained release. DTX-NPs were prepared by nanotemplate engineering technique with palmityl alcohol as a solid lipid and Tween-40/Span-40/Myrj S40 as a surfactants mixture. Spherical DTX-NPs below 100 nm were successfully prepared with a narrow particle size distribution, 96% of incorporation efficiency and 686 times increase in DTX solubility. DTX-NPs showed a sustained release over 24 h in phosphate-buffered saline and simulated gastric and intestinal fluids, while DTX-micelles released DTX completely within 12 h. The half-maximal inhibitory concentration (IC50) of DTX-NPs against human breast cancer MCF-7 cells was 1.9 times lower than that of DTX-micelles and DTX solution. DTX-NPs demonstrated 3.7- and 2.8-fold increase in the area under the plasma concentration-time curve compared with DTX-micelles after oral and parenteral administration, respectively.
URI
https://www.tandfonline.com/doi/abs/10.1080/02652048.2017.1337247http://repository.hanyang.ac.kr/handle/20.500.11754/72162
ISSN
0265-2048; 1464-5246
DOI
10.1080/02652048.2017.1337247
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE