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Prion Diagnosis: Application of Real-Time Quaking-Induced Conversion

Title
Prion Diagnosis: Application of Real-Time Quaking-Induced Conversion
Author
류종석
Keywords
CREUTZFELDT-JAKOB-DISEASE; CHRONIC WASTING DISEASE; CEREBROSPINAL-FLUID; NASAL BRUSHINGS; VARIANT CJD; PROTEIN; SCRAPIE; TISSUES; PATHOGENESIS; ASSAY
Issue Date
2017-05
Publisher
HINDAWI PUBLISHING CORP
Citation
BIOMED RESEARCH INTERNATIONAL, V. 2017, Article ID 5413936
Abstract
Prions composed of pathogenic scrapie prion protein (PrPSc) are infectious pathogens that cause progressive neurological conditions known as prion diseases or transmissible spongiform encephalopathies. Although these diseases pose considerable risk to public health, procedures for early diagnosis have not been established. One of the most recent attempts at sensitive and specific detection of prions is the real-time quaking-induced conversion (RT-QuIC) method, which measures the activity of PrPSc aggregates or amyloid formation triggered by PrPSc seeds in the presence of recombinant PrP. In this review, we summarize prions, prion diseases, and current approaches to diagnosis, including the principle, conditions for assay performance, and current diagnostic applications of RT-QuIC.
URI
https://www.hindawi.com/journals/bmri/2017/5413936/abs/http://repository.hanyang.ac.kr/handle/20.500.11754/72067
ISSN
2314-6133; 2314-6141
DOI
10.1155/2017/5413936
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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