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Evaluation of Herb-Drug Interactions of Hovenia dulcis Fruit Extracts

Title
Evaluation of Herb-Drug Interactions of Hovenia dulcis Fruit Extracts
Author
유혜현
Keywords
Hovenia dulcis; Herb-drug interactions; CYP450; inhibition; CYTOCHROME-P450 ISOFORMS; MEDICINES; METABOLISM; INHIBITION; THUNB; MICE
Issue Date
2017-05
Publisher
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
Citation
PHARMACOGNOSY MAGAZINE, v. 13, Page. 236-239
Abstract
Background: Hovenia dulcis (Rhamnaceae) fruits are popularly used as herbal medicines or dietary supplements in Asian countries due to functions such as liver protection and detoxification from alcohol poisoning. Accordingly, it is very likely for dietary supplemental products, including H. dulcis fruit extracts, to be taken with prescription drugs. Objective: In this study, possible food-drug interactions involving H. dulcis fruit extracts were evaluated based on the inhibition of cytochrome P450 (CYP) enzyme activity. Material and Methods: The water extract of H. dulcis fruit extracts was incubated in human liver microsomes with CYP-specific substrates. The formation of the CYP-specific metabolites was measured using liquid chromatography-tandem mass spectrometry. Results: H. dulcis fruit extracts showed negligible effects on seven CYP isozyme activities at all concentrations tested. Conclusion: This result suggests that H. dulcis fruit extracts may have minimal pharmacokinetic interactions with coadministered drugs through the modulation of CYP enzymes.
URI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421419/http://repository.hanyang.ac.kr/handle/20.500.11754/72054
ISSN
0973-1296; 0976-4062
DOI
10.4103/0973-1296.204552
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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