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dc.contributor.author류종석-
dc.date.accessioned2018-06-14T04:22:05Z-
dc.date.available2018-06-14T04:22:05Z-
dc.date.issued2017-05-
dc.identifier.citationJOURNAL OF MICROENCAPSULATION, v. 34, No. 3, Page. 250-261en_US
dc.identifier.issn0265-2048-
dc.identifier.issn1464-5246-
dc.identifier.urihttps://www.tandfonline.com/doi/abs/10.1080/02652048.2017.1337247-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/72053-
dc.description.abstractThe aim of this study was to develop docetaxel-incorporated lipid nanoparticles (DTX-NPs) to improve the pharmacokinetic behaviour of docetaxel (DTX) after oral and parenteral administration via sustained release. DTX-NPs were prepared by nanotemplate engineering technique with palmityl alcohol as a solid lipid and Tween-40/Span-40/Myrj S40 as a surfactants mixture. Spherical DTX-NPs below 100 nm were successfully prepared with a narrow particle size distribution, 96% of incorporation efficiency and 686 times increase in DTX solubility. DTX-NPs showed a sustained release over 24 h in phosphate-buffered saline and simulated gastric and intestinal fluids, while DTX-micelles released DTX completely within 12 h. The half-maximal inhibitory concentration (IC50) of DTX-NPs against human breast cancer MCF-7 cells was 1.9 times lower than that of DTX-micelles and DTX solution. DTX-NPs demonstrated 3.7- and 2.8-fold increase in the area under the plasma concentration-time curve compared with DTX-micelles after oral and parenteral administration, respectively.en_US
dc.description.sponsorshipThis work was supported by the research fund of Hanyang University (HY-2012-N).en_US
dc.language.isoen_USen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.subjectLipid nanoparticlesen_US
dc.subjectdocetaxelen_US
dc.subjectsustained releaseen_US
dc.subjectpharmacokineticsen_US
dc.subjectbioavailabilityen_US
dc.subjectCONTROLLED DRUG-DELIVERYen_US
dc.subjectIN-VIVO EVALUATIONen_US
dc.subjectANTICANCER DRUGSen_US
dc.subjectTUMOR MICROENVIRONMENTen_US
dc.subjectVITROen_US
dc.subjectCYTOTOXICITYen_US
dc.subjectNANOCARRIERSen_US
dc.subjectCARRIERSen_US
dc.subjectSYSTEMSen_US
dc.subjectSLNen_US
dc.titleSustained release docetaxel-incorporated lipid nanoparticles with improved pharmacokinetics for oral and parenteral administrationen_US
dc.typeArticleen_US
dc.relation.no3-
dc.relation.volume34-
dc.identifier.doi10.1080/02652048.2017.1337247-
dc.relation.page250-261-
dc.relation.journalJOURNAL OF MICROENCAPSULATION-
dc.contributor.googleauthorQureshi, Omer Salman-
dc.contributor.googleauthorKim, Hyung-Seo-
dc.contributor.googleauthorZeb, Alam-
dc.contributor.googleauthorChoi, Jin-Seok-
dc.contributor.googleauthorKim, Hoo-Seong-
dc.contributor.googleauthorKwon, Jung-Eun-
dc.contributor.googleauthorKim, Myung-Sic-
dc.contributor.googleauthorKang, Jong-Ho-
dc.contributor.googleauthorRyou, Chongsuk-
dc.contributor.googleauthorPark, Jeong-Sook-
dc.contributor.googleauthorKim, Jin-Ki-
dc.relation.code2017001623-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidcryou2-
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