Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유혜현 | - |
dc.date.accessioned | 2018-06-11T05:11:11Z | - |
dc.date.available | 2018-06-11T05:11:11Z | - |
dc.date.issued | 2017-04 | - |
dc.identifier.citation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v. 27, No. 8, Page. 1826-1830 | en_US |
dc.identifier.issn | 0960-894X | - |
dc.identifier.issn | 1464-3405 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0960894X17301798 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/71966 | - |
dc.description.abstract | Paradols are unsaturated ketones produced by biotransformation of shogaols in gingers. Among them, 6-paradol has been investigated as a new drug candidate due to its anti-inflammatory, apoptotic, and neuroprotective activities. In this study, the inhibitory effects of 6-paradol on the activities of cytochrome P450 (CYP) enzymes were investigated with human liver microsomes and recombinant CYP isozymes. 6-Paradol showed concentration-dependent inhibitory effects on CYP1A2, CYP2B6, CYP2C8, CYP2C9, and CYP2C19 isozymes, with IC50, values ranging from 3.8 to 21.4 mu M in recombinant CYP isozymes. However, the inhibition was not potentiated following pre-incubation, indicating that 6-paradol is not a mechanism-based inhibitor. These results suggest that pharmacokinetic drug-drug interactions might occur with 6-paradol, which must be considered in the process of new drug development. (C) 2017 Elsevier Ltd. All rights reserved. | en_US |
dc.description.sponsorship | This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF-2014R1A1A1A05002840). Prof. Hye Hyun Yoo is an Invitation Research Fellow of the Japan Society for the Promotion of Science in 2016. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | en_US |
dc.subject | 6-Paradol | en_US |
dc.subject | Unsaturated ketone | en_US |
dc.subject | Ginger | en_US |
dc.subject | CYP inhibition | en_US |
dc.subject | Drug-drug interaction | en_US |
dc.subject | ENZYMES | en_US |
dc.title | Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism | en_US |
dc.type | Article | en_US |
dc.relation.no | 8 | - |
dc.relation.volume | 27 | - |
dc.identifier.doi | 10.1016/j.bmcl.2017.02.047 | - |
dc.relation.page | 1826-1830 | - |
dc.relation.journal | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.contributor.googleauthor | Kim, Hyeong Jun | - |
dc.contributor.googleauthor | Kim, In Sook | - |
dc.contributor.googleauthor | Rehman, Shaheed Ur | - |
dc.contributor.googleauthor | Ha, Sang Keun | - |
dc.contributor.googleauthor | Nakamura, Katsunori | - |
dc.contributor.googleauthor | Yoo, Hye Hyun | - |
dc.relation.code | 2017000739 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | yoohh | - |
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