52 0

Synergistic anticancer activity of combined histone deacetylase and proteasomal inhibitor-loaded zein nanoparticles in metastatic prostate cancers

Title
Synergistic anticancer activity of combined histone deacetylase and proteasomal inhibitor-loaded zein nanoparticles in metastatic prostate cancers
Author
최한곤
Keywords
Zein nanoparticles; Bortezomib; Vorinostat; Prostate cancer; LIQUID-CRYSTALLINE NANOPARTICLES; GRAPHENE OXIDE; DRUG-DELIVERY; LIPID NANOPARTICLES; ANDROGEN RECEPTOR; BREAST-CANCER; CELLS; BORTEZOMIB; VORINOSTAT; RELEASE
Issue Date
2017-03
Publisher
ELSEVIER SCIENCE BV
Citation
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, v. 13, No. 3, Page. 885-896
Abstract
The development of resistance and subsequent metastasis makes prostate cancer a leading cause of cancer-related death among men. Hence, nanoparticle-based combination chemotherapeutics could be a viable treatment strategy. Weaimed to prepare vorinostat (Vor) and bortezomib (Bor) combination-loaded zein nanoparticles (ZNP, ZNP/VB) for treating metastatic prostate cancers. Our results revealed the successful preparation of ZNP/VB with a small particle size (similar to 160 nm) and polydispersity index (similar to 0.20). Importantly, controlled and pH-dependent drug release profiles were observed. ZNP/VB exhibited high uptake in different prostate cancer cells and, thereby, exhibited higher cytotoxicity and apoptosis. Additionally, the enhanced anti-migration effect of and induction of pro-apoptotic proteins by ZNP/VB suggest its potential effectiveness in cancer treatment. ZNP/VB showed enhanced in vivo antitumor effects compared to that observed for each free drug and their combination, with minimal toxicity. Taken together, ZNP/VB could be a potential formulation for the effective treatment of metastatic prostate cancers. (C) 2016 Elsevier Inc. All rights reserved.
URI
https://www.ncbi.nlm.nih.gov/pubmed/27993720http://repository.hanyang.ac.kr/handle/20.500.11754/71849
ISSN
1549-9634; 1549-9642
DOI
10.1016/j.nano.2016.12.010
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE