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The Pathophysiologic Mechanism of Tinnitus

Title
The Pathophysiologic Mechanism of Tinnitus
Author
정재호
Keywords
Tinnitus; Pathophysiology; Mechanism
Issue Date
2016-05
Publisher
한양대학교 의과대학
Citation
Hanyang Medical Reviews, v. 36, NO 2, Page. 81-85
Abstract
Tinnitus represents a phantom auditory sensation without an external sound source. The reported prevalence of tinnitus estimates 15-20% in world population. Although severe tinnitus might be associated with deterioration of quality of life, depression and anxiety, treatment modalities of tinnitus have not been established yet. Considering the heterogeneity of tinnitus, a single theory or a hypothesis cannot sufficiently explain the mechanism of tinnitus. Thus, diverse theories and studies had been conducted to elucidate the secret of tinnitus. Degeneration of outer hair cell in the peripheral auditory system is known to be associated with tinnitus, while auditory plasticity theory, upregulation of excitation of central auditory structures explains the role of the central auditory pathway in the generation of tinnitus. In addition, somatosensory and limbic autonomic nervous systems are also deeply involved with the pathogenesis of tinnitus. Herein, recent pathophysiologic theories and remarkable studies of tinnitus were reviewed. Understanding of the mechanism of the tinnitus generation might be the cornerstone in the development of tinnitus treatment.
URI
https://synapse.koreamed.org/DOIx.php?id=10.7599/hmr.2016.36.2.81http://repository.hanyang.ac.kr/handle/20.500.11754/71588
ISSN
1738-429X; 2234-4446
DOI
https://doi.org/10.7599/hmr.2016.36.2.81
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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