Nanoencapsulation of Red Ginseng Extracts Using Chitosan with Polyglutamic Acid or Fucoidan for Improving Antithrombotic Activities

Title
Nanoencapsulation of Red Ginseng Extracts Using Chitosan with Polyglutamic Acid or Fucoidan for Improving Antithrombotic Activities
Author
이지수
Keywords
red ginseng extracts; chitosan nanoparticles; ionic gelation; platelet aggregation; antithrombotic activity
Issue Date
2016-05
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v. 64, NO 23, Page. 4765-4771
Abstract
The potential of nanoencapsulation using bioactive coating materials for improving antithrombotic activities of red ginseng extract (RG) was examined. RG-loaded chitosan (CS) nanoparticles were prepared using antithrombotic materials, polyglutamic acid (PGA) or fucoidan (Fu). Both CS-PGA (P-NPs, 360 +/- 67 nm) and CS-Fu nanoparticles (F-NPs, 440 +/- 44 nm) showed sustained ginsenoside release in an acidic environment and improved ginsenoside solubility by approximately 122.8%. Both in vitro rabbit and ex vivo rat platelet aggregation of RG (22.3 and 41.5%) were significantly (p ˂ 0.05) decreased within P-NPs (14.4 and 30.0%) and F-NPs (12.3 and 30.3%), respectively. Although RG exhibited no effect on in vivo carrageenan-induced mouse tail thrombosis, P-NPs and F-NPs demonstrated significant effects, likely the anticoagulation activity of PGA and Fu. Moreover, in the in vivo rat arteriovenous shunt model, P-NPs (156 +/- 6.8 mg) and F-NPs (160 +/- 3.2 mg) groups showed significantly lower thrombus formation than that of RG (190 +/- 5.5 mg). Therefore, nanoencapsulation using CS, PGA, and Fa is a potential for improving the antithrombotic activity of RG.
URI
https://pubs.acs.org/doi/10.1021/acs.jafc.6b00911http://repository.hanyang.ac.kr/handle/20.500.11754/71519
ISSN
0021-8561; 1520-5118
DOI
10.1021/acs.jafc.6b00911
Appears in Collections:
RESEARCH INSTITUTE[S](부설연구소) > KOREAN LIVING SCIENCE RESEARCH INSTITUTE(한국생활과학연구소) > Articles
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