Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 임태연 | - |
dc.date.accessioned | 2018-05-21T05:12:36Z | - |
dc.date.available | 2018-05-21T05:12:36Z | - |
dc.date.issued | 2016-05 | - |
dc.identifier.citation | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, v. 8, NO 3, Page. 246-256 | en_US |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.issn | 2092-7363 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.4168/aair.2016.8.3.246 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/71413 | - |
dc.description.abstract | Purpose: Diesel exhaust particles (DEPs) can induce and trigger airway hyperresponsiveness (AHR) and inflammation. The aim of this study was to investigate the effect of long-term DEP exposure on AHR, inflammation, lung fibrosis, and goblet cell hyperplasia in a mouse model. Methods: BALB/c mice were exposed to DEPs 1 hour a day for 5 days a week for 3 months in a closed-system chamber attached to a ultrasonic nebulizer (low dose: 100 mu g/m(3) DEPs, high dose: 3 mg/m(3) DEPs). The control group was exposed to saline. Enhanced pause was measured as an indicator of AHR. Animals were subjected to whole-body plethysmography and then sacrificed to determine the performance of bronchoalveolar lavage and histology. Results: AHR was higher in the DEP group than in the control group, and higher in the high-dose DEP than in the low-dose DEP groups at 4, 8, and 12 weeks. The numbers of neutrophils and lymphocytes were higher in the high-dose DEP group than in the low-dose DEP group and control group at 4, 8, and 12 weeks. The levels of interleukin (IL)-5, IL-13, and interferon-gamma were higher in the low-dose DEP group than in the control group at 12 weeks. The level of IL-10 was higher in the high-dose DEP group than in the control group at 12 weeks. The level of vascular endothelial growth factor was higher in the low-dose and high-dose DEP groups than in the control group at 12 weeks. The level of IL-6 was higher in the low-dose DEP group than in the control group at 12 weeks. The level of transforming growth factor-beta was higher in the high-dose DEP group than in the control group at 4, 8, and 12 weeks. The collagen content and lung fibrosis in lung tissue was higher in the high-dose DEP group at 8 and 12 weeks. Conclusions: These results suggest that long-term DEP exposure may increase AHR, inflammation, lung fibrosis, and goblet cell hyperplasia in a mouse model. | en_US |
dc.description.sponsorship | This research was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (2013R1A1A2005465) and Soonchunhyang University Research Fund. | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY | en_US |
dc.subject | Chronic | en_US |
dc.subject | diesel exhaust particles | en_US |
dc.subject | airway remodeling | en_US |
dc.title | Long-Term Effects of Diesel Exhaust Particles on Airway Inflammation and Remodeling in a Mouse Model | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 8 | - |
dc.identifier.doi | 10.4168/aair.2016.8.3.246 | - |
dc.relation.page | 246-256 | - |
dc.relation.journal | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.contributor.googleauthor | Kim, Byeong-Gon | - |
dc.contributor.googleauthor | Lee, Pureun-Haneul | - |
dc.contributor.googleauthor | Lee, Shin-Hwa | - |
dc.contributor.googleauthor | Kim, Young-En | - |
dc.contributor.googleauthor | Shin, Mee-Yong | - |
dc.contributor.googleauthor | Kang, Yena | - |
dc.contributor.googleauthor | Bae, Seong-Hwan | - |
dc.contributor.googleauthor | Kim, Min-Jung | - |
dc.contributor.googleauthor | Rhim, TaiYoun | - |
dc.contributor.googleauthor | Park, Choon-Sik | - |
dc.relation.code | 2016011514 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | rhim | - |
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