Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배옥남 | - |
dc.date.accessioned | 2018-05-14T05:38:29Z | - |
dc.date.available | 2018-05-14T05:38:29Z | - |
dc.date.issued | 2016-12 | - |
dc.identifier.citation | BIOCHEMICAL PHARMACOLOGY, v. 122, Page. 72-79 | en_US |
dc.identifier.issn | 0006-2952 | - |
dc.identifier.issn | 1873-2968 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0006295216303069 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/71357 | - |
dc.description.abstract | In this study, we investigated the effects of antibiotics on the pharmacological effects of aspirin. The antithrombotic activity of aspirin was evaluated after antibiotic treatment using tail bleeding assay. The pyrosequencing analysis and selective medium culture assay were performed to investigate the alterations in gut microbiota. In addition, the in vitro metabolism assay with fecal suspension and in vivo pharmacokinetic experiments with antibiotic treatment were conducted. Ampicillin treatment "significantly prolonged the bleeding time in aspirin-dosed rats. Oral administration of ampicillin significantly reduced gut microbial aspirin-metabolizing activity by 67.0% in rats. Furthermore, systemic exposure to aspirin and its primary metabolite (M1) was significantly increased in ampicillin-treated rats. The results from the pyrosequencing and selective medium culture with rat fecal samples revealed that ampicillin treatment led to the changes of the amounts and composition profile of gut microbiota. These findings suggest that co-administration of antibiotics can modulate the metabolism and pharmacokinetics of aspirin via suppression of metabolic activity of gut microbiota, which could potentiate the therapeutic potency of aspirin. (C) 2016 Elsevier Inc. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by a grant from the Ministry of Food and Drug Safety in 2016 [16182MFDS416] and by a grant from the National Research Foundation of Korea [NRF-2014R1A1A1A05002840]. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | en_US |
dc.subject | Aspirin | en_US |
dc.subject | Antithrombotic effect | en_US |
dc.subject | Metabolism | en_US |
dc.subject | Antibiotics | en_US |
dc.subject | Gut microbiota | en_US |
dc.subject | PERSONALIZED MEDICINE | en_US |
dc.subject | BIOAVAILABILITY | en_US |
dc.subject | XENOBIOTICS | en_US |
dc.subject | PROJECT | en_US |
dc.subject | DRUGS | en_US |
dc.subject | ACID | en_US |
dc.subject | RATS | en_US |
dc.title | Reduced metabolic activity of gut microbiota by antibiotics can potentiate the antithrombotic effect of aspirin | en_US |
dc.type | Article | en_US |
dc.relation.volume | 122 | - |
dc.identifier.doi | 10.1016/j.bcp.2016.09.023 | - |
dc.relation.page | 72-79 | - |
dc.relation.journal | BIOCHEMICAL PHARMACOLOGY | - |
dc.contributor.googleauthor | Kim, In Sook | - |
dc.contributor.googleauthor | Yoo, Dae-Hyeong | - |
dc.contributor.googleauthor | Jung, Il-Hoon | - |
dc.contributor.googleauthor | Lim, Sumin | - |
dc.contributor.googleauthor | Jeong, Jin-Ju | - |
dc.contributor.googleauthor | Kim, Kyeong-A | - |
dc.contributor.googleauthor | Bae, Ok-Nam | - |
dc.contributor.googleauthor | Yoo, Hye Hyun | - |
dc.contributor.googleauthor | Kim, Dong-Hyun | - |
dc.relation.code | 2016000808 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | onbae | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.