43 0

Reduced metabolic activity of gut microbiota by antibiotics can potentiate the antithrombotic effect of aspirin

Title
Reduced metabolic activity of gut microbiota by antibiotics can potentiate the antithrombotic effect of aspirin
Author
유혜현
Keywords
Aspirin; Antithrombotic effect; Metabolism; Antibiotics; Gut microbiota; PERSONALIZED MEDICINE; BIOAVAILABILITY; XENOBIOTICS; PROJECT; DRUGS; ACID; RATS
Issue Date
2016-12
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOCHEMICAL PHARMACOLOGY, v. 122, Page. 72-79
Abstract
In this study, we investigated the effects of antibiotics on the pharmacological effects of aspirin. The antithrombotic activity of aspirin was evaluated after antibiotic treatment using tail bleeding assay. The pyrosequencing analysis and selective medium culture assay were performed to investigate the alterations in gut microbiota. In addition, the in vitro metabolism assay with fecal suspension and in vivo pharmacokinetic experiments with antibiotic treatment were conducted. Ampicillin treatment "significantly prolonged the bleeding time in aspirin-dosed rats. Oral administration of ampicillin significantly reduced gut microbial aspirin-metabolizing activity by 67.0% in rats. Furthermore, systemic exposure to aspirin and its primary metabolite (M1) was significantly increased in ampicillin-treated rats. The results from the pyrosequencing and selective medium culture with rat fecal samples revealed that ampicillin treatment led to the changes of the amounts and composition profile of gut microbiota. These findings suggest that co-administration of antibiotics can modulate the metabolism and pharmacokinetics of aspirin via suppression of metabolic activity of gut microbiota, which could potentiate the therapeutic potency of aspirin. (C) 2016 Elsevier Inc. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0006295216303069http://repository.hanyang.ac.kr/handle/20.500.11754/71356
ISSN
0006-2952; 1873-2968
DOI
10.1016/j.bcp.2016.09.023
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE